Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-777-6
CAS number: 110-54-3
Perbellini et al. (1981) measured metabolites in shoe workers exposed to
n-hexane. Mean concentrations of n-hexane metabolites in urine were:
2,5-hexanedione, 5.4 mg/L; 2,5-dimethylfuran, 3.7 mg/L;
gamma-valerolactone, 3.3 mg/L; and 2-hexanol, 0.19 mg/L.
(2,5-Dimethylfuran and gammavalerolactone were believed to be artifacts
of sample preparation and analysis rather than true metabolites of
nhexane) (ATSDR 1999). The first reaction that takes place is
hydroxylation of n-hexane at the 2 position to form 2-hexanol. Further
reactions result in 2,5-hexanedione, presumably through transient
intermediates, including 2-hexanone, 2,5-hexanediol, and
5-hydroxy-2-hexanone. Correlations between concentrations of n-hexane in
air and urinary metabolites were best for total n-hexane metabolites
(r=0.7858), followed by 2 -hexanol (r=0.6851) and 2,5 -hexanedione
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again