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EC number: 203-777-6
CAS number: 110-54-3
worker long-term exposure DNELs for systemic effects are based on the
Indicative Occupational Exposure Limit (IOEL) for n-hexane. The
inhalation DNEL is the IOEL, the NOAEC of 225 mg/m³ based on AF of 3.
The assessment factor used has been derived by combining all the
contributing assessment factors, which include allometric scaling,
worker population, exposure duration, dose-response and quality of
study of Governa et al. (1987) was used by the EC Scientific Committee
for Occupational Exposure Limits to establish the IOEL for n-hexane. This
study indicated that electroneuroyographic abnormalities occurred in
workers with concentrations of 2,5-hexanedione in post-shift urine
greater than 7.5 mg/L, which corresponded to an 8-hour time weighted
average of about 70 ppm (250 mg/m3) and this is a LOAEL for
effects on the peripheral nervous system. An assessment factor of 3 was
applied to account for intraspecies differences among workers.
dermal DNEL was calculated by multiplying the IOEL by 10 m2 (the
volume of air breathed) and divided by 70 kg (the average worker body
weight). An assessment factor of three was applied. The assessment
factor used has been derived by combining all the contributing
assessment factors, which include allometric scaling, worker popultion,
exposure duration, dose-response and quality of database.
is not classified as acutely toxic according to OECD GHS guidelines;
therefore, acute / short-term DNELs were not derived.
exposure at levels significantly higher than the systemic DNELs results
in local effects (nasal lesions). The
systemic DNELs are protective for both systemic and local effects,
therefore DNELs for local effects were not derived.
general population long-term exposure DNELs for systemic effects are
based on the Indicative Occupational Exposure Limit (IOEL) for n-hexane.
The inhalation DNEL is the IOEL multiplied by 10/20 to correct for
differences between worker and general population ventilation rates, 5/7
to correct for days per week potentially exposed, and 3/5 to use an
assessment factor of 5 for intraspecies differences. The dermal and oral
DNELs were calculated by multiplying the inhalation DNEL by 20 m3
(the volume of air a person breathes in a day) and dividing by 60 kg
(average body weight of general population).
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