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EC number: 239-290-0
CAS number: 15245-44-0
Lead acetate induced a dose-related increase in micronuclei frequency,
with all doses producing statistically significant increases in the
frequency of micronucleated PNEs. Lead acetate also reduced the number
of PCEs per total erythrocytes in the blood of treated animals.
However, the doses of lead applied were of sufficient duration and
intensity to induce anaemia in the test animals. Anaemia, whether
induced by chemical or other (blood loss) means has been demonstrated to
result in similar increases in micronuclei. It is not possible to
determine if the positive finding is an effect of lead or an indirect
nonspecific effect related to anaemia induction.
Female Wistar rats were treated by gavage once per week for 10 weeks
with cumulative doses of 140, 250, and 500 mg/kg lead acetate and
genotoxicity was evaluated in erythrocytes from whole blood via the
micronucleus test. Lead acetate induced a dose-related increase in
micronuclei frequency, with all doses producing statistically
significant increases in the frequency of micronucleated PNEs. Lead
acetate also reduced the number of PCEs per total erythrocytes in the
blood of treated animals.
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