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EC number: 239-290-0
CAS number: 15245-44-0
Sparingly soluble lead compounds do not exhibit irritant or corrosive properties.
Reliable animal data were found
indicating that lead oxide, lead phosphite and dibasic lead phthalate
lack irritating properties for the skin or the eyes. The
experimental data are reinforced by a lack of reports of skin or eye
irritation in the many occupational exposure environments which provide
opportunities for exposure of lead and sparingly soluble lead compounds
to the skin and eyes. Classification
for these endpoints is clearly not needed. Specific
studies of lung irritation were not found, but the lack of inhalation
toxicity from lead oxide in both acute toxicity testing and inhalation
cancer bioassays combine with an absence of reports of lung irritation
in occupational settings to suggest classification is not needed.
The substances for which data are
available should permit data waiving for a number of other substances. The
three tested compounds are all sparingly soluble (and thus unlikely to
undergo significant dissolution when applied to the skin, eyes or
tested compounds further include one compound with an organic anion and
one with an inorganic anion. Literature searches
have failed to identify anions in other sparingly soluble substances
that would alter the irritant properties of other sparingly soluble lead
dermal, oral and inhalation toxicity studies for lead compounds are
uniformly negative and further support a finding of no irritant
waiving for all irritant classification endpoints should thus be
possible for metallic lead and other sparingly soluble lead salts
(unless anions are present that literature searches
suggest might impart irritating properties.
No studies were found documenting corrosive properties of lead and
sparingly soluble lead compounds in either experimental animals or
humans. Given the negative findings of acute toxicity and irritation
studies and the absence of reports from occupationally exposed workers,
corrosive properties are not to be expected of lead or its sparingly
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