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EC number: 239-290-0
CAS number: 15245-44-0
This acute, oral toxicity study was conducted to assess the
toxicological potential of dibasic lead phthalate in adult male and
female rats in order to insure compliance with Department of
Transportation regulations covering the transport of poisonous
materials. The test material was suspended in 0.25% sodium
carboxymethylcellulose and administered in volume doses of 1 ml/kg to
young adult male and female Sprague Dawley derived rats. During the
range finding test, groups of two males and two females received 250,
500, 1000, or 2000 mg/kg doses of dibasic lead phthalate. Animals were
observed for signs of systemic toxicity and after 14 days they were
subjected to complete gross necropsy which included visual examination
of the mucosal surface of the gastrointestinal tracts. During the
estimation of the acute oral LD50 value, groups of three male and three
female rats received oral doses of 2000 mg/kg of dibasic lead phthalate.
Animals were weighed and observed daily for 14 days then they were
sacrificed and subjected to complete necropsy.
There was no evidence of either local or systemic toxicological
consequences associated with the oral administration of dibasic lead
phthalate. Body weight gains of dosed animals were similar to those of
concurrent controls and there were no gross pathological findings that
could be attributed to the administration of dibasic lead phthalate.
Therefore, the acute oral LD50 value of dibasic lead phthalate in male
and female rats is greater than 2000 mg/kg and the Lowest Observable
Effect Level (LOEL) is also greater than 2000 mg/kg.
It is concluded that dibasic lead phthalate affords no acute
toxicological hazard as defined by the Department of Transportation and
requires no special consideration during transport.
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