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EC number: 239-290-0
CAS number: 15245-44-0
Mean values of ocular reactions at 24, 48 and 72 hours after treatment (test eye) R
Conjunctivae redness 1.00 - Some blood vessels definitely hyperaemic
2.00- Diffuse, Crimson colour,
individual vessels not easily discernible
Conjunctivae chemosis 0 -No swelling; 1.00 Any swelling above normal;
2.00 Obvious swelling with partial eversion of lids
The potential toxicity of "PEBETAL dibasic lead phthalate" was assessed
in an acute eye irritation/corrosion test on 3 albino rabbits. In each
animal, 0.1 g of the test article was introduced into the conjunctival
sac of the right eye, the untreated left eye served as control. Both
eyes were examined at 1, 24, 48, and 72 hours post applicationem.
The following results were obtained;
Redness and chemosis of the conjunctivae, grade 2, were observed in the
animals 1 hour after instillation and in one rabbit up to day 5 or 6
after instillation. Moderate discharge was observed in all animals at 1
hour after instillation and was seen in one out of three animals also at
24 hours after instillation. Additionally, bloody vessels of the eyeball
were seen in one animal between 24 hours and day 6 after instillation.
No general toxic effects were observed.
The observed ocular findings were fully reversible within 7 days after
instilllation in all animals.
The mean grades of findings were 1.00, 1.00, and 2.33 for redness of the
conjunctivae and 0.67, 0.33 and 2.00 for chemosis of the conjunctivae
The mean grades of ocular reactions at 24,48 and 72 hours after
instillation were lower than the value classified as irritant by the EEC
Directive 2001/59/EEC of 6 August 2001 and the Gefahrstofffverordnung
(GefStoffV) of 15 November 1999 (BGB1. I, p.2233) When administered to
the eye, the test article "PEBETAL dibasic lead phthalate" may be
classified as "non-irritant."
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