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EC number: 239-290-0
CAS number: 15245-44-0
The acute dermal toxicity of "PEBETAL dibasic lead phthalate" was
investigated in one group of rats comprising 5 males and 5 females. On
the basis of the range finding test, the animals were given a single
dermal administration of "PEBETAL dibasic lead phthalate" at the dose of
2000 mg/kg. The skin was exposed to the test article for 24 hours.
Clinical observations were carried out at regular intervals during the
14 -day observation period. Signs of erythma and oedema were evaluated
once daily for 14 days. Body weights were determined immediately before treatment
and on days 7 and 14 p.a. Gross pathological examinations were carried
out at study termination on all animals. The following results were
-No animal died during the 14 -day observation period.
-No abnormal clinical signs were observed.
-No signs os skin irritation were observed.
-The body weight development was slightly influenced in some animals
during the first week after treatment, possibly due to the
administration procedure as such. At the end of the study, 14 days after
treatment, the body weights were in the normal range. Gross pathological
examinations on day 14 p.a. did not reveal any findings in the rats.
Since no deaths were caused in Wistar rats after the dermal treatment
with the test article "PEBETAL dibasic lead phthlate"
of 2000 mg/kg, the LD50 values after 24hours and 14 days were as follows:
Male and Female >2000 mg/kg
The above value is higher than the limit specified as harmful by the EEC
Directive 2001/59/EEC of 6 August 2001 and the Gefahrstoffverordnung
(GefStoffV) of 15 November 1999 (BGB1.I, p.2233). When administered by
the dermal route, the test article
"PEBETAL dibasic lead phthalate may therefore be classified as
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