Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Lead 2,4,6-trinitro-m-phenylene dioxide
  • IUPAC name: 6,8,9-trinitro-2,4-dioxa-3-plumbabicyclo[3.3.1]nona-1(9),5,7-triene
  • Other names
EC / List no.:
239-290-0
CAS no.:
15245-44-0
Index number:
609-019-00-4; 609-019-01-1
Molecular formula:
C6HN3O8Pb
SMILES:
[O-][N+](=O)c1cc(c2O[Pb]Oc1c2[N+]([O-])=O)[N+]([O-])=O
InChI:
InChI=1S/C6H3N3O8.Pb/c10-5-2(7(12)13)1-3(8(14)15)6(11)4(5)9(16)17;/h1,10-11H;/q;+2/p-2 AuxInfo=1/1/N:5,4,6,12,11,7,2,16,13,10,8,1,3,17,18,14,15;9/E:(2,3)(5,6)(7,8)(10,11)(12,13,14,15)(16,17);/CRV:7.5,8.5,9.5;/rA:18O-N+OCCCCOPbOCCN+O-ON+O-O/rB:s1;d2;s2;d+4;s5;d-6;s7;s8;s9;s4s10;s7d-11;s12;s13;d13;s6;s16;d16;/rC:7.1992,-7.3881,0;6.9935,-5.8595,0;8.2182,-4.9228,0;5.5718,-5.2759,0;5.5718,-3.7311,0;4.4871,-2.6462,0;2.9503,-2.6462,0;1.8573,-3.7311,0;1.8573,-5.2759,0;2.9503,-6.3609,0;4.4871,-6.3609,0;2.6462,-4.9472,0;1.2245,-5.539,0;0,-4.6023,0;1.019,-7.0594,0;5.0786,-1.2245,0;6.5992,-1.019,0;4.1419,0,0;
Type of substance:
Mono constituent substance
Origin:
Organometallic
Registered compositions:
7
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in CLP notifications this substance is an unstable explosive, may damage fertility or the unborn child, causes damage to organs through prolonged or repeated exposure, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, is harmful if swallowed and is harmful if inhaled.

This substance is covered by several Harmonised Classifications and Labelling's (CLH) entries approved by the European Union. Differentiating between the different CLH's entries requires manual verification. To know more about the CLH please visit the C&L Inventory.

Breakdown of all 21 C&L notifications submitted to ECHA

Repr. 1A H360
Aquatic Acute 1 H400
Acute Tox. 4 H302
Acute Tox. 4 H332
Unst. Expl. H200
STOT RE 1 H372
Aquatic Chronic 2 H411
Aquatic Chronic 1 H410
STOT RE 2 H373
Expl. 1.1 H201
Repr. 1A H360Df
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • R

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 9 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
This substance is subject to the Prior Informed Consent regulation and to export notification procedure from 03-Dec-2015
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 - 100 tonnes per year.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery).

This substance is used in the following products: explosives.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals at non-dedicated facilities.

Other release to the environment of this substance is likely to occur from: outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance is used in the following products: explosives.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, mixing in open batch processes, transfer of substance into small containers and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and in the production of articles.

This substance is used in the following products: explosives.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: fabricated metal products.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, mixing in open batch processes, transfer of substance into small containers and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and in the production of articles.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • CHEDDITE FRANCE SA, 99 route de Lyon BP112 26501 Bourg Les Valence Cedex Rhone Alpes France
  • Eley Ltd, Selco Way Minworth Industrial Estate B76 1BA Sutton Coldfield West Midlands United Kingdom
  • Fiocchi Munizioni S.p.A., Via Santa Barbara, 4 23900 LECCO LC Italy
  • Lapua GmbH, Wilhelm-Dümling-Straße 12 39218 Schönebeck Germany
  • MAXAM UEB, S.L., Barrio de Zuazo, s/n 48960 Galdácano Vizcaya Spain
  • NCS Pyrotechnie et Technologies, Rue de la Cartoucherie BP 90010 95471 FOSSES CEDEX France
  • NOBEL SPORT MARTIGNONI S.P.A., CORSO DI PORTA NUOVA, 15 20121 MILANO Italy
  • RUAG Ammotec GmbH, Kronacher Straße 63 90765 Fürth Bayern Germany
  • Sellier Bellot J.S.C., Lidická 667 258 13 Vlašim Czech Republic

Other names

  • -
  • 6,8,9-trinitro-2,4-dioxa-3-plumbabicyclo[3.3.1]nona-1(9),5,7-triene
  • Lead 2,4,5-trinitro-m-phenylene
  • lead 2,4,6-trinitro-m-phenylene dioxide
  • Lead 2,4,6-trinitrobenzene-1,3-diolate
  • Lead styphnate
  • Lead 2,4,6-trinitro-m-phenylene dioxide
  • lead 2,4,6-trinitroresorcinoxide
  • Lead styphnate
  • lead styphnate (≥ 20 % phlegmatiser)
  • Bleistyphnat
  • lead 2,4,6-trinitroresorcinoxide
  • lead styphnate
  • lead trinitroresorcinate
  • Premix -mixture
  • TNR OF LEAD

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Crystalline (100%) [1]
C Substance type
Organometallic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Melting/freezing point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Boiling point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Vapour pressure

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 1 study submitted
  • 1 study processed
R Log Pow
-2.19 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-2.19 @ 20 °C

Water solubility

Study results
  • 2 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
500 - 900 mg/L @ 20 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 47 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 47
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 13 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 42 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 19 2 19
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 6.5 µg/L (1)
Intermittent releases (freshwater) 70 µg/L (1)
Marine water 3.4 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 100 µg/L (1)
Sediment (freshwater) 174 mg/kg sediment dw (1)
Sediment (marine water) 164 mg/kg sediment dw (1)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 147 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 10.9 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 45 studies submitted
  • 36 studies processed
P/RResults
LC50 (4 days) 40.8 - 3 597.9 µg/L [37]
LC50 (48 h) 114 - 610 µg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 7 1
Weight of evidence 35
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 74 studies submitted
  • 44 studies processed
P/RResults
NOEC (3 months) 48 µg/L [2]
NOEC (84 days) 39.4 - 176.3 µg/L [4]
NOEC (60 days) 70 - 136 µg/L [4]
NOEC (32 days) 107.7 µg/L [4]
NOEC (30 days) 29.3 - 448.9 µg/L [8]

Type of Study provided
Studies with data
Key study 44
Supporting study 30
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 146 studies submitted
  • 89 studies processed
P/RResults
EC50 (48 h) 7.02 mg/L [1]
LC50 (4 days) 590.94 µg/L [2]
LC50 (48 h) 26 - 3 115.8 µg/L [86]
EC10 (72 h) 111.2 - 252.3 µg/L [8]
EC10 (48 h) 9.2 - 1 409.6 µg/L [15]

Type of Study provided
Studies with data
Key study 17
Supporting study 56 1
Weight of evidence 72
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 52 studies submitted
  • 36 studies processed
P/RResults
NOEC (4.2 months) 143.3 - 757.2 µg/L [2]
NOEC (4 months) 12 µg/L [1]
NOEC (34 days) 109 µg/L [1]
NOEC (30 days) 31 µg/L [1]
NOEC (25 days) 20 - 153.8 µg/L [2]

Type of Study provided
Studies with data
Key study 36
Supporting study 16
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 22 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 21.7 - 322.9 µg/L [7]
NOEC (4 days) 22.7 - 192.3 µg/L [2]
LOEC (4 days) 44.3 - 298.1 µg/L [2]
EC10 (4 days) 29.4 - 1 231.8 µg/L [4]
EC10 (48 h) 4.5 - 93 µg/L [7]

Type of Study provided
Studies with data
Key study 3
Supporting study 18 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
IC10 (7 days) 29.5 - 643.2 µg/L [6]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 28 studies submitted
  • 3 studies processed
P/RResults
IC50 (9 h) 180 mg/L [1]
EC10 (24 h) 7 mg/L [1]
IC10 (24 h) 1 - 2.79 mg/L [3]
IC10 (60 min) 2.92 - 9.59 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 15 1
Weight of evidence 9
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
1 mg/L

Sediment toxicity

Study results
  • 12 studies submitted
  • 9 studies processed
P/RResults
NOEC (35 days) 1 699 mg/kg sediment dw [2]
NOEC (28 days) 503 - 4 719 mg/kg sediment dw [12]
NOEC (21 days) 1 126 - 2 903 mg/kg sediment dw [3]
NOEC (20 days) 3 390 - 5 230 mg/kg sediment dw [2]
LOEC (35 days) 2 734 mg/kg sediment dw [2]

Type of Study provided
Studies with data
Key study 9
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 11 studies submitted
  • 7 studies processed
P/RResults
NOEC (3.733 months) 130 mg/kg soil dw [1]
NOEC (56 days) 1.822 - 2.202 g/kg soil dw [2]
NOEC (28 days) 400 - 3 125 mg/kg soil dw [8]
NOEC (21 days) 608 mg/kg soil dw [1]
EC10 (84 days) 2.03 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study
Supporting study 4
Weight of evidence 7
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 5 studies submitted
  • 5 studies processed
P/RResults
NOEC (42 days) 400 mg/kg soil dw [1]
EC10 (28 days) 697 - 4 718 mg/kg soil dw [7]
LC50 (35 days) 980 - 2 200 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 5
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 17 studies submitted
  • 12 studies processed
P/RResults
NOEC (4.433 months) 150 mg/kg soil dw [1]
NOEC (42 days) 150 - 287 mg/kg soil dw [2]
NOEC (40 days) 190 - 1 697.5 mg/kg soil dw [10]
NOEC (5 days) 89 - 169 mg/kg soil dw [4]
EC10 (4.433 months) 358 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study
Supporting study 5
Weight of evidence 12
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 22 studies submitted
  • 10 studies processed
P/RResults
NOEC (1.726 years) 8.042 g/kg soil dw [1]
NOEC (1.534 years) 8.13 g/kg soil dw [1]
NOEC (10.033 months) 163 mg/kg soil dw [1]
NOEC (28 days) 100 - 810 mg/kg soil dw [2]
NOEC (21 days) 500 - 3 800 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study 12
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 14 studies submitted
  • 14 studies processed
P/RResults
NOEC (7 months) 50 mg/kg diet [3]
NOEC (84 days) 25 - 2 000 mg/kg diet [7]
NOEC (75 days) 100 mg/kg diet [4]
NOEC (70 days) 200 mg/kg diet [1]
NOEC (60 days) 264 mg/kg diet [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 12
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
100 mg/kg food

Toxicity to mammals

Study results
  • 13 studies submitted
  • 13 studies processed
P/RResults
NOEC (1.227 years) 550 mg/kg diet [2]
NOEC (1.159 years) 64 mg/kg diet [1]
NOEC (11.1 months) 512 mg/kg diet [1]
NOEC (6.3 months) 1 000 mg/kg diet [3]
NOEC (84 days) 1 000 mg/kg diet [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1 12
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence 1
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 9 studies submitted
  • 8 studies processed
P/RResults
rat 84 days () [1]
LD50 2 000 - 5 000 mg/kg bw (rat) [7]
M/CInterpretations of results
Practically nontoxic [8]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study
Weight of evidence 7
Other 1
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 5.05 mg/L air (rat) [1]
M/CInterpretations of results
Practically nontoxic [1]

inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 4 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [3]
M/CInterpretations of results
Practically nontoxic [3]

dermal
Studies with data
Key study 1
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 2 studies processed
P/RResults
LOAEL (rat): 200 ppm [1]
NOEL (rat): 0.002 mg/kg bw/day [1]
LOEL (rat): 0.005 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study
Supporting study 12 1
Weight of evidence 5
Other
Data waiving
no waivers
Study data: in vivo
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 5
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 9
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant