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EC number: 218-747-8
CAS number: 2224-33-1
One male rat was given a single dose of 550 mg/kg bw of the test
substance by oral gavage. The animal showed no adverse effects within 3
days of dosing and appeared healthy. A second fastened male was dosed
with 2000 mg/kg bw and also showed no adverse effects within 3 days of
dosing and appeared healthy. A third male rat was dosed with 2000 mg/kg
bw and showed adverse effects which were fully reversible within 3 days.
Another rat was dosed with 2000 mg/kg bw and also showed adverse
effects, which were reversible within 3 days.
An acute oral toxicity test was performed according to OECD 425 and GLP
on butan-2-one O,O',O''-(vinylsilanetriyl)oxime. No mortality was
observed and the LD50 was determined to be >2000 mg/kg bw in rats.Two
of three rats showed transient adverse clinical signs which were
no longer evident on day 3.
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