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Long-term toxicity to aquatic invertebrates

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Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Studies conducted by the Japanese Ministry of the Environment based on based on OECD-GLP standard and OECD test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Deviations:
yes
Remarks:
(no details on method)
GLP compliance:
yes
Analytical monitoring:
yes
Details on sampling:
High performance liquid chromatography (HPLC) on day 0, 2, 11, 14 and 18.
Test organisms (species):
Daphnia magna
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
21 d
Test temperature:
20 ± 1ºC
Nominal and measured concentrations:
25.0, 50.0, 100.0 mg/L
Details on test conditions:
TEST SYSTEM
- Test vessel: 80 mL
- Renewal rate of test solution (frequency/flow rate): 3 times per week
- No. of organisms: 10 organisms per concentration.

OTHER TEST CONDITIONS
- Photoperiod: 16 hours light/ 8 hous dark
- Light intensity: 1200 lux
Duration:
21 d
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks:
(parent daphnia)
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
>= 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Validity criteria fulfilled:
not specified
Conclusions:
The 21d-EC50 and 21d-NOEC (basis for effect: reproduction) for 2-butanone oxime in Daphnia magna was determined to be > 100 mg/L and >= 100 mg/L respectively. The 21d-LC50 of parent daphnids was > 100 mg/L.
Executive summary:

A Daphnia magna reproduction test was performed by the Japanese Ministry of the Environment according to OECD TG 211. The test was performed during 21 days. The 21d-EC50 and 21d-NOEC (basis for effect: reproduction) for test substance 2 -butanone oxime in Daphnia magna was determined to be > 100 mg/L and >=100 mg/L respectively. The 21d-LC50 of parent daphnids was > 100 mg/L.

Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Butan-2-one O,O',O''-(vinylsilanetriyl)oxime undergoes rapid hydrolysis in aqueous to butanone oxime and the corresponding silanol. Silanetriol undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the observed toxicity is likely due to butanone oxime and their values are comparable.
See attached the reporting format.
Reason / purpose:
read-across source
Duration:
21 d
Dose descriptor:
LC50
Effect conc.:
> 119.94 mg/L
Nominal / measured:
estimated
Conc. based on:
other: (analogue substance)
Basis for effect:
mortality
Remarks:
(parental daphnia)
Remarks on result:
other: (read-across approach from an analogue)
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
> 119.94 mg/L
Nominal / measured:
estimated
Conc. based on:
other: (analogue substance)
Basis for effect:
reproduction
Remarks on result:
other: (read-across approach from an analogue)
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
>= 119.94 mg/L
Nominal / measured:
estimated
Conc. based on:
other: (analogue substance)
Basis for effect:
reproduction
Remarks on result:
other: (read-across approach from an analogue)
Details on results:
Based on the experimental results obtained in a Daphnia magna Reproduction Test on the analogue substance 2-butanone oxime (21d-LC50 > 100 mg/L, 21d-EC50 > 100 mg/L and 21d-NOEC >= 100 mg/L ), the read-across approach was applied and the 21-LC50 (based on parental mortality) of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in Daphnia magna was determined to be > 119.94 mg/L, the 21-EC50 (based on reproduction) > 119.94 mg/L and the 21d-NOEC (based on reproduction) >= 119.94 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on the read-across approach from experimental data on the analogue substance butanone oxime, the 21-LC50 (based on parental mortality) of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in Daphnia magna was determined to be > 119.94 mg/L, the 21-EC50 (based on reproduction) > 119.94 mg/L and the 21d-NOEC (based on reproduction) >= 119.94 mg/L
Executive summary:

A Daphnia magna reproduction test was performed by the Japanese Ministry of the Environment according to OECD TG 211. The test was performed during 21 days. The 21d-EC50 (basis for effect: reproduction) and 21d-NOEC for test substance butanone oxime in Daphnia magna was determined to be >100 mg/L. The 21d-LC50 of parent daphnias was > 100 mg/L. Based on these results the read-across approach was applied and the 21-LC50 (based on parental mortality) of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in Daphnia magna was determined to be > 119.94 mg/L, the 21-EC50 (based on reproduction) > 119.94 mg/L and the 21d-NOEC (based on reproduction) >= 119.94 mg/L.

Description of key information

Key study: Read-across from experimental data on analogue butanone oxime: The 21-LC50 (based on parental mortality) of butan-2-one O,O',O''-(vinylsilanetriyl)oxime  in Daphnia magna was determined to be > 119.94 mg/L, the 21-EC50 (based on reproduction) > 119.94 mg/L and the 21d-NOEC (based on reproduction) >= 119.94 mg/L

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
119.94 mg/L

Additional information

Key study: Read-across approach from analogue 2-butanone oxime:

Based on the read-across approach from experimental results on analogue butanone oxime (test method OECD 211, 21d-LC50 > 100 mg/L, 21d-EC50 > 100 mg/L and 21d-NOEC >= 100 mg/L), the 21-LC50 (based on parental mortality) of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in Daphnia magna was determined to be > 119.94 mg/L, the 21-EC50 (based on reproduction) > 119.94 mg/L and the 21d-NOEC (based on reproduction) >= 119.94 mg/L