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EC number: 218-747-8
CAS number: 2224-33-1
Short-term toxicity to fish. Key study: LC50 (96h) = 1011.11 mg/L (based
on mortality) (read-across from supporting substance butanone oxime).
Long-term toxicity to fish. Key study: LC50 (14d) > 119.94 mg/L (based
on mortality) and NOEC (14d) = 59.97 mg/L (read-across from supporting
substance butanone oxime).
Short-term toxicity to aquatic invertebrates: Key study: EC50 (48h) =
241.08 mg/L (based on mobility) (read-across from supporting substance
Long-term toxicity to aquatic invertebrates: Key study: LC50 (21d) >
119.94 mg/L (based on parental mortality), EC50 (21d) > 119.94 mg/L
(based on reproduction) and NOEC (21d) >= 119.94 mg/L (based on
reproduction) (read-across from supporting substance butanone oxime).
Toxicity to aquatic algae: Key study: EC50 (72h) = 19.19 mg/L and NOEC
(72h) = 3.12 mg/L (based on growth rate) (read-across from analogue
substance butanone oxime)
silicon chemicals are known as silanes. A silane that contains at least
one silicon carbon bond, (e.g -Si-CH3) is an organosilane. They normally
contain two different types of reactive groups: the hydrolysable groups
such as methoxy, ethoxy or acetoxy groups and the organo-functional
group, such as epoxy, amino, methacryloxy, or sulfido. It is well known
that the Si-OR bonds hydrolyse readily with water, even if only with
moisture absorbed on the surface, to form silanol Si-OH groups. These
silanol groups can then condense with each other to form polymeric
structures with very stable siloxane Si-O-Si bonds.
to confirm that hydrolysis of silanes is fast, several hydrolysis tests
have been conducted in analogue silanes.In
the hydrolysis test performed on propyltriacetoxysilane, the process was
very fast. The half-life at different pH of test item was determined to
be < 37.5 seconds since it completely hydrolysed at 150 seconds after
the initial contact with water.
Moreover, the hydrolysis
test performed on two acetone oxime silanes, more than 50% of the
components hydrolysed in less than 0.75hafter
starting the dissolution of the test substance at
25 ºC and independently of the pH.
it is stated in different publications, silanols hydrolyse well in water
and the carbon- bounded substituents can have profound effects on the
rate of hydrolysis. (Arkles B., Chemtech 1977; Pluddemann E. P., Plenum
Press NY, 1982; Kay, B. D. and Assink R. A, J. Non-Cryst. Solids, 1988).
rates of hydrolysis of the alkoxy groups are generally related to their
steric bulk: CH3O>C2H5O> t-C4H9O
and a methoxysilane hydrolyzes at 6-10 times rate of an ethoxysilane.
Smith (Smith K. J. Org. Chem 1986) proved that increased organic
substitution enhances the hydrolysis rate Me3SiOMe> Me2Si(OMe)2>
the hydrolysis test performed with propyltriacetoxysilane, the
condensation and polimerysation of the molecules formed in hydrolysis
were observed too. It was observed as the phase separation.
Unfortunately, this phase separation caused the technical difficulties
of the determination of the molecular weight of larger condensation
products. It was possible to determined MW of smaller condensates which
still are in solutions. Their
average MW were between 604-695.
phase separation as a result of condensation was described by Arkles.
The hydrolysis of propyltrimetoxysilane showed that oligomers are formed
and branched structures presages phase separation (Arkles B. et al,
Silanes and Coupling Agents, 1992).
in account both, the hydrolysis and condensation, it is expected that
the observed in the hydrolysis test phase changed product contains large
chain polymers with MW>1000.
showed that molecules of MW>1000 cannot be biologically available (Van
Gestel et a, Reg. Toxicol. and Pharmacol., 1985, 5, 422-31 and Zitko V,
Handbook of Environmental Chemistry, v. 2 221-29).
stated before, oximino silanes are not stable when exposed to water or
moisture and undergo rapid hydrolysis. The hydrolysis of
butan-2-one-O,O’,O’’-(vinylsilyldyne) trioxime produces 3 moles of
butanone oxime and the silanetriol which condensate to higher molecular
weight siloxanes. The polymerization products are considered
biologically unavailable and the toxicity is driven by butanone oxime.
toxicity of butan-2-one-O,O’,O’’-(vinylsilyldyne) trioxime should be
evaluated as the toxicity of butanone oxime.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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