Butan-2-one O,O',O''-(vinylsilylidyne)trioxime

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

06 Nov 1986 - 26 Nov 1986

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

adopted 1981

Deviations:

no

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Butan-2-one O,O',O''-(vinylsilylidyne)trioxime

EC Number:

218-747-8

EC Name:

Butan-2-one O,O',O''-(vinylsilylidyne)trioxime

Cas Number:

2224-33-1

Molecular formula:

C14H27N3O3Si

IUPAC Name:

N-[Bis[[(E)-butan-2-ylideneamino]oxy]-ethenylsilyl]oxybutan-2-imine

Details on test material:

- Name of test material (as cited in study report): Catalyseur 30 532 – vinyltris(méthyléthylcétiminoxy)silane
- Substance type: Ketoxime
- Physical state: Liquid
- Storage condition of test material: Original container

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Iffa-Crédo, FRANCE
- Age at study initiation: 5-7 wk
- Weight at study initiation: (mean, g) 196 (m) 178 (f)
- Fasting period before study: no data
- Housing: 1/stainless steel mesh cage
- Diet: rat pelleted complete maintenance diet (U.A.R. formula "A.04), ad libitum
- Water: drinking water ad libitum
- Acclimation period: 1 wk

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12

IN-LIFE DATES: (initial and main study) from: 1986-11-06 To: 1986-11-26

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: 10%
- Type of wrap if used: perforated bandage on gauze bandage

REMOVAL OF TEST SUBSTANCE
- Washing: wiped at end of exposure with gauze
- Time after start of exposure: 24 h

TEST MATERIAL
- Amount applied: 2.05 ml/kg bw

Duration of exposure:

24 h

Doses:

pre-study: 1000, 2009 mg/kg bw
main study: 2009 mg/kg bw

No. of animals per sex per dose:

Pre-study: 2
Main study: 5

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations at 0, 1, 2, 4 h, then daily for 14 days; weighing weekly
- Necropsy of survivors performed: yes

Statistics:

Bliss
Litchfield & Wilcoxon

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 009 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality occurred.

Mortality:

none

Clinical signs:

other: none

Gross pathology:

No treatment-related effects were observed.

Other findings:

No local erythema and oedema were observed.

Applicant's summary and conclusion

Interpretation of results:

other: Not classified (CLP Regulation EC no. 1272/2008)

Conclusions:

A reliable dermal acute limit study conducted in compliance with a standard guideline and in accordance with GLP (reliability score 1), identified an LD50 > 2009 mg/kg bw in male and female rats. No local effects were reported.

Executive summary:

A limit study conducted in compliance with OECD 402 and in accordance with GLP, butan-2-one O,O',O''-(vinylsilanetriyl)oxime identified a LD50 for of > 2009 mg/kg bw in male and female rats. No effects were reported.