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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
06 Nov 1986 - 26 Nov 1986
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Version / remarks:
adopted 1981
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Butan-2-one O,O',O''-(vinylsilylidyne)trioxime
EC Number:
218-747-8
EC Name:
Butan-2-one O,O',O''-(vinylsilylidyne)trioxime
Cas Number:
2224-33-1
Molecular formula:
C14H27N3O3Si
IUPAC Name:
N-[Bis[[(E)-butan-2-ylideneamino]oxy]-ethenylsilyl]oxybutan-2-imine
Details on test material:
- Name of test material (as cited in study report): Catalyseur 30 532 – vinyltris(méthyléthylcétiminoxy)silane
- Substance type: Ketoxime
- Physical state: Liquid
- Storage condition of test material: Original container

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Iffa-Crédo, FRANCE
- Age at study initiation: 5-7 wk
- Weight at study initiation: (mean, g) 196 (m) 178 (f)
- Fasting period before study: no data
- Housing: 1/stainless steel mesh cage
- Diet: rat pelleted complete maintenance diet (U.A.R. formula "A.04), ad libitum
- Water: drinking water ad libitum
- Acclimation period: 1 wk

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12

IN-LIFE DATES: (initial and main study) from: 1986-11-06 To: 1986-11-26

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: 10%
- Type of wrap if used: perforated bandage on gauze bandage

REMOVAL OF TEST SUBSTANCE
- Washing: wiped at end of exposure with gauze
- Time after start of exposure: 24 h

TEST MATERIAL
- Amount applied: 2.05 ml/kg bw
Duration of exposure:
24 h
Doses:
pre-study: 1000, 2009 mg/kg bw
main study: 2009 mg/kg bw
No. of animals per sex per dose:
Pre-study: 2
Main study: 5
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations at 0, 1, 2, 4 h, then daily for 14 days; weighing weekly
- Necropsy of survivors performed: yes
Statistics:
Bliss
Litchfield & Wilcoxon

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 009 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality occurred.
Mortality:
none
Clinical signs:
other: none
Gross pathology:
No treatment-related effects were observed.
Other findings:
No local erythema and oedema were observed.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
A reliable dermal acute limit study conducted in compliance with a standard guideline and in accordance with GLP (reliability score 1), identified an LD50 > 2009 mg/kg bw in male and female rats. No local effects were reported.
Executive summary:

A limit study conducted in compliance with OECD 402 and in accordance with GLP, butan-2-one O,O',O''-(vinylsilanetriyl)oxime identified a LD50 for of > 2009 mg/kg bw in male and female rats. No effects were reported.