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Long-term toxicity to fish

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Endpoint:
long-term toxicity to fish, other
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Studies conducted by the Japanese Ministry of the Environment based on based on OECD-GLP standard and OECD test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
Deviations:
yes
Remarks:
(no details on method)
GLP compliance:
yes
Analytical monitoring:
yes
Details on sampling:
High performance liquid chromatography (HPLC) on day 0, 7 and 14.
Test organisms (species):
Oryzias latipes
Test type:
flow-through
Water media type:
freshwater
Limit test:
no
Total exposure duration:
14 d
Test temperature:
24 ± 1 ºC
Nominal and measured concentrations:
6.25, 12.5, 25.0, 50.0, 100.0 mg/L
Details on test conditions:
TEST SYSTEM
- Test vessel: 1.8 L
- Aeration: No
- Type of flow-through (e.g. peristaltic or proportional diluter): no data.
- No. of organisms: 10 animals per concentration.

OTHER TEST CONDITIONS
- Photoperiod: 16 hours light/ 8 hours dark

TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2.0
Reference substance (positive control):
not specified
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Key result
Duration:
14 d
Dose descriptor:
NOEC
Effect conc.:
50 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: no data
Validity criteria fulfilled:
not specified
Conclusions:
The 14d-LC50 and 14d-NOEC of 2-butanone oxime in fish (Oryzias lapides) was determined to be >100 and 50 mg/L respectively.
Executive summary:

A fish prolonged toxicity test was performed by the Japanese Ministry of the Environment according to OECD TG 204. The test duration was 14 days. The 14 d-LC50 and 14d-NOEC of test substance 2 -butanonen oxime in fish (Oryzias lapides) was determined to be >100 and 50 mg/L respectively.

Endpoint:
long-term toxicity to fish, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Butan-2-one O,O',O''-(vinylsilanetriyl)oxime undergoes rapid hydrolysis in aqueous to butanone oxime and the corresponding silanol. Silanetriol undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the observed toxicity is likely due to butanone oxime and their values are comparable.
See attached the reporting format.
Reason / purpose:
read-across source
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
> 119.94 mg/L
Nominal / measured:
estimated
Conc. based on:
other: (analogue substance)
Basis for effect:
mortality
Remarks on result:
other: (read-across from an analogue substance)
Key result
Duration:
14 d
Dose descriptor:
NOEC
Effect conc.:
59.97 mg/L
Nominal / measured:
estimated
Conc. based on:
other: (analogue substance)
Basis for effect:
other: no data
Remarks on result:
other: (read-acros from an analogue substance)
Details on results:
Based on the experimental results obtained in the Fish, Prolonged Toxicity Testwith on the analogue substance butanone oxime (14d-LC50 >100 mg/L and 14d-NOEC = 50 mg/L ), the read-across approach was applied and the 14d-LC50 and 14d-NOEC of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in fish (Oryzias lapides) was determined to be >119.94 and 59.97 mg/L respectively.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on the read-across approach from experimental results on analogue butanone oxime, the 14d-LC50 and 14d-NOEC of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in fish (Oryzias lapides) was determined to be >119.94 and 59.97 mg/L respectively.
Executive summary:

A fish Prolonged Toxicity Test: 14-day Study was performed on analogue substance butanone oxime by the Japanese Ministry of the Environment according to OECD 204. The 14d-LC50 in fish (Oryzias lapides) was determined to be >100 mg/L and the 14d-NOEC was 50 mg/L. Based on these results, the read-across approach was applied and the 14d-LC50 and 14d-NOEC of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in fish (Oryzias lapides) was determined to be >119.94 and 59.97 mg/L respectively.

Description of key information

Key study: Read-across from experimental data on analogue butanone oxime. The 14d-LC50 and 14d-NOEC of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in fish (Oryzias lapides) was determined to be >119.94 and 59.97 mg/L respectively.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
59.97 mg/L

Additional information

Read-across approach from analogue butanone oxime:

Key study: Based on the read-across approach from experimental data on analogue butanone oxime (test method equivalent to OECD 204, 14d-LC50 in fish (Oryzias lapides) > 100 mg/L and 14d-NOEC = 50 mg/L), the read-across approach was applied and the 14d-LC50 and 14d-NOEC of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in fish (Oryzias lapides) was determined to be >119.34 and 59.97 mg/L respectively.