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EC number: 203-529-7
CAS number: 107-88-0
A bacterial mutagenicity test (according to OECD guidelines 471
and 472 and GLP-compliant) was performed in Salmonella typhimurium
TA1535, TA1537, TA98 and TA100, and in Escherichia coli WP2 uvrA as
preincubation test, with and without metabolic activation.
Tests with and without S9 mix were conducted twice, within the
range of 313 -5000 μg/plate with a common ratio of 2.
For the test of TA1537, without the addition of S9 mix, the result
in Test I for the 625 μg/plate showed an increase in revertant colony
count which was more than twice that of the solvent control value.
However, in the testing of TA1537 with the addition of S9 mix and in the
tests with all the other bacteria, there was no increase in revertant
colony count more than twice that of the solvent control.
For TA1537, since the results without S9 mix were different for
Test I and Test II, the main test was repeated using identical doses. As
a result, no increase in revertant colony count more than twice that of
the solvent control was noted.
In all of the tests conducted, the positive control group showed
an increase in revertant colony count for all of the test bacteria,
which meant that, along with the values measured for the solvent control
group, the revertant colony count was within the range of historical
values, so the efficacy of this test series was confirmed.
It is concluded, based on the above results that the test material
is not mutagenic (negative) for the test strains used.
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