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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1949
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1949
Report Date:
1949
Reference Type:
publication
Title:
Unnamed
Report Date:
1949

Materials and methods

Principles of method if other than guideline:
acute skin irritation test
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 1,3-Butylenglykol

Test animals

Species:
rat
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
other: shaved or abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
2 h
Details on study design:
The rats were exposed to the test substance for 2 h at the shaved or abraded abdominal skin

Results and discussion

In vivo

Results
Irritation parameter:
other: overall evaluation
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No signs of irritation were observed

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Under the conditions of this study, the test substance was not irritating to the skin.
Executive summary:

Rats were exposed for 2 h to neat test substance at the abdominal intact or abraded abdominal skin. No signs of irritation were oberved (Fischer et al.,1949; Loeser, 1949).