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EC number: 203-529-7
CAS number: 107-88-0
Nominal concentration (mg/L)
The effects of 1,3 -butanediol on the
respiration rate of activated sludge were tested in a 3 -h respiration
inhibition test following OECD TG 209. Three test concentrations plus
two controls (0 mg/L) were set up: 1, 10, 100 mg/L. The highest
concentration was tested in triplicate. 3,5 -DCP was used as reference
compound and was tested at 3, 10 and 32 mg/L. With the test substance no
adverse effects were measured up to 100 mg/L. Therefore, the 3 -h EC50
is > 100 mg/L. The validity criteria were fulfilled. Disturbances of
waste water treatment processes are not to be expected when 1,3
-butanediol is released in appropriate amounts.
3-h EC50 (respiration inhibition of activated sludge) > 100 mg/L (OECD
TG 209, Barnes, 1999)
40h-IGC50 (growth inhibiting effect to ciliate Tetrahymena pyriformis) =
18035 mg/L (TETRATOX assay, Schultz, 1997)
Weight of evidence approach for toxicity to microorganisms of
There were two studies available that tested the toxicitiy of butane-1,3
-diol to microorganisms. In the first study, the effects of 1,3
-butanediol on the respiration rate of activated sludge were tested in a
3 -h respiration inhibition test following OECD TG 209 (RL2). Three test
concentrations plus two controls (0 mg/L) were set up: 1, 10, 100 mg/L.
The highest concentration was tested in triplicate. The test substance
showed no adverse effects up to 100 mg/L. Therefore, the 3 -h EC50 > 100
mg/L. The validity criteria were fulfilled. In the other study, the
growth inhibiting effect of 1,3 -butanediol on the ciliate Tetrahymena
pyriformis was determined using the TETRATOX assay (RL2). The
resulting IGC50 (40 h) of 18035 mg/L indicated no significant toxicity
of 1,3 -butanediol to microorganisms (ciliates).
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