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EC number: 203-529-7
CAS number: 107-88-0
The acute toxicity of the test substance is low. This is based on oral LD50 values > 10000 mg/kg bw in several species, no lethal effects in the rat at 8 h exposure to saturated vapour concentration and a dermal LD50 > 20000 mg/kg bw as well as a low toxicity after parenteral application.
Non-fasted male rats were given single oral doses of the test item. The
LD50 (observation period: 14 days) was 22800 mg/kg bw (Smyth et al.,
No deaths occurred.
No lethal effects were observed in male rats after a single 8 h of
exposure to saturated vapour (concentration not stated, about 78 ppm or
292 mg/m3) (Smyth et al., 1951).
The available data indicate that that the oral, inhalation and dermal
acute toxicity of 1,3 -BG is low.
A reliable study (key study) reports an oral LD50 of 22800 mg/kg bw in
rats (Smyth et al., 1951).
The reported range of oral LD50 values in the rat is 18610-22800 mg/kg
bw (Smyth et al., 1941, 1951), in the mouse is 12980-25130 mg/kg bw
(Dominguez-Gil et al., 1971; Fischer et al., 1949; Loeser, 1949; Wenzel
et al., 1956), and the LD50 in guinea pigs is 11640 mg/kg bw (Smyth et
No LD50 values could be identified for the inhalative route, but rats
exposed to saturated vapour (about 78 ppm or 292 mg/m3) did not show
lethal effects (Smyth et al., 1951, key study). A dermal LD50 in rabbits
of >20000 mg/kg is reported in a secondary source (RL4) (ChemID, 2008).
This value is supported by the absence of toxic effects after repeated
dermal exposure of guinea pigs to 20 ml/kg (20100 mg/kg bw, Kopf et al.,
1950). By the parenteral route, there are reported LD50 values of 20170
mg/kg bw (subcutaneous, rat; Fischer et al., 1949), 10000 mg/kg bw
(intraperitoneal, rat; Sprince et al,. 1966) and 9000 mg/kg bw
(intravenous, rat; BIBRA, 1990).
Based on the available data, which indicate a low acute toxicity, and
according to Regulation (EC) No 1272/2008 no classification for acute
toxicity is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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