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EC number: 203-529-7
CAS number: 107-88-0
Cumulative rates from liver perfusates expressed as µmol of 1,3-butylene
glycol/90 min per g dry weight (mean +/- S.E.M.)
Contribution of 1,3 -butylene glycol to total ketogenesis. Cumulative
rates are expressed as µmol of 1,3-butylene glycol/90 min per g dry
weight (mean +/- S.E.M.)
Total rates of fatty acid and sterol synthesis. All rates are expressed
as µmol acetyl incorporated/90 min per g dry weight (means +/- S.E.M)
Livers from fed and starved rats were perfused with buffer containing
radiolabelled R- or S-1,3-butylene glycol. The following parameters were
determined: a) uptake of the diol, b) contribution of the diol to
ketogenesis, c) contribution of the diol to total fatty acid plus sterol
synthesis, and d) conversion of S-1,3-butylene glycol into the (non
physiological) metabolite S-3-hydroxybutyrate. Both enantiomers were
taken up by the livers of fed or starved rats at the same rate.
R-1,3-butylene glycol is mainly transformed to the physiological ketone
bodies R-3-hydroxybutyrate and acetoacetate. Only 29-38% of the
S-enantiomer are converted into physiological ketone bodies. The
S-enantiomer is further metabolised to S-3-hydroxybutyrate (not a
natural compound), lipids and carbon dioxide (Desrochers et al., 1992).
Using radiolabelled substrate they could demonstrate that the
R-1,3-butylene glycol is metabolised to physiological ketone bodies and
the S-enantiomer to S-3 -hydroxybutyrate , lipids and carbon dioxide.
Based on the results obtained it was concluded that the test item is
metabolised via physiological pathways, suggesting that the substance is
not accumulate in the body.
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