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EC number: 203-529-7
CAS number: 107-88-0
Mortality: no mortality or symptoms were
noted during exposure
[% of nominal]
The acute toxicity of 1,4 -butanediol was
tested under semi-static conditions in a 96 -h toxicity study on the
killifish (Oryzias latipes) following OECD TG 203. Analytical
verification of the test substance concentrations at test start and
after renewal (48 h) revealed recovery rates of > 80 %. Based on nominal
concentrations, the 96 -h LC50 was determined to be > 100 mg/L.
96-h LC50 > 100 mg/L (OECD 203, Env. Agency of Japan, 1997)
Read-across approach: butane-1,4 -diol (source), butane-1,3 -diol
(target) (see also Read-across justification in IUCLID section 13)
In the available key study, acute toxicity of the source substance 1,4
-butanediol was tested under semi-static conditions in a 96 -h toxicity
study on the killifish (Oryzias latipes) following OECD TG 203 (RL1).
Analytical verification of the test substance concentrations at test
start and after renewal (48 h) revealed recovery rates of > 80 %. Based
on nominal concentrations, the 96 -h LC50 was determined to be > 100
mg/L for source and target substance (no conversion factor applied as
source and target compound have the same molecular weight). In the
supporting prolonged toxicity study, adverse effects of 1,4 -butanediol
was tested under flow-through conditions in a 14 -d toxicity study on
the Medaka/Killifish (Oryzias latipes) following OECD TG 204 (RL1). A
limit test with 100 mg/L and a control were set up. Analytical
verification of the test substance concentrations at test start, after 7
and 14 d revealed recovery rates of > 80 %. Based on nominal
concentrations, the 14 -d LC50 was determined to be > 100 mg/L for
source and target substance. Calculated results are available for 1,3
-butanediol, indicating that the acute toxicity to fish is beyond 1000
mg/L (e.g. FoBiG, 2017, RL2). Reagrding the remaining studies only
abstracts are available, the reliability score is 4 (not assignable),
but the results are published under reviewed programmes and by reliable
organisations like ECB (see summary of results below).
study; measured; analytical monitoring
Environmental Agency of Japan, 1997
measred; analytical monitoring
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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