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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Study details are reported incompletely.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1949
Report Date:
1949

Materials and methods

GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 1,3-Butylenglykol, pure substance

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
unchanged (no vehicle)
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
20.06 mL/kg bw
Sex:
not specified
Dose descriptor:
LD50
Effect level:
20 170 mg/kg bw
Remarks on result:
other: calculated (density of 1.0053, according to CTFA, 1985)

Any other information on results incl. tables

Sublethal and lethal doses produced loss of muscle tonus, lethargic, prone position, accelerated respiration and later gasped respiration and lateral position. Lethal doses further caused narcosis, absence of reflexes and respiratory paralysis.

Applicant's summary and conclusion

Conclusions:
The acute toxicity by the subcutaneous route was low.
Executive summary:

After single subcutaneous administration of the test substance to rats the LD50 was 20170 mg/kg bw (Fischer et al., 1949).