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EC number: 224-320-7 | CAS number: 4306-88-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not provided
- Details on results:
- The retention time of the 2,6-Di-tert-butyl-4-nonylphenol was > 40 min and hence longer than the retention time of the reference material with the highest logPow, i.e., a logPow of 6.5 (4,4´-DDT). Therefore the logPow of 2,6-Di-tert-butyl-4-nonylphenol is reported to be > 6.5.
- Conclusions:
- logPow: > 6.5
- Executive summary:
In the Klimisch 1 GLP-study Bär (2016) determined the logPow of 2,6-Di-tert-butyl-4-nonylphenol according to OECD 117 (HPLC-method). The retention time of the 2,6-Di-tert-butyl-4-nonylphenol was > 40 min and hence longer than the retention time of the reference material with the highest logPow, i.e., a logPow of 6.5 (4,4´-DDT). Therefore the logPow of 2,6-Di-tert-butyl-4-nonylphenol is reported to be > 6.5.
The information is considered relevant and reliable for the risk assessment.
Reference
Description of key information
log Pow: > 6.5
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.5
- at the temperature of:
- 20 °C
Additional information
In the Klimisch 1 GLP-study Bär (2016) determined the logPow of 2,6-Di-tert-butyl-4-nonylphenol according to OECD 117 (HPLC-method). The retention time of the 2,6-Di-tert-butyl-4-nonylphenol was > 40 min and hence longer than the retention time of the reference material with the highest logPow, i.e., a logPow of 6.5 (4,4´-DDT). Therefore the logPow of 2,6-Di-tert-butyl-4-nonylphenol is reported to be > 6.5.
The information is considered relevant and reliable for the risk assessment.
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