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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
> 6.5
Temp.:
20 °C
Remarks on result:
other: pH not provided
Details on results:
The retention time of the 2,6-Di-tert-butyl-4-nonylphenol was > 40 min and hence longer than the retention time of the reference material with the highest logPow, i.e., a logPow of 6.5 (4,4´-DDT). Therefore the logPow of 2,6-Di-tert-butyl-4-nonylphenol is reported to be > 6.5.
Conclusions:
logPow: > 6.5
Executive summary:

In the Klimisch 1 GLP-study Bär (2016) determined the logPow of 2,6-Di-tert-butyl-4-nonylphenol according to OECD 117 (HPLC-method). The retention time of the 2,6-Di-tert-butyl-4-nonylphenol was > 40 min and hence longer than the retention time of the reference material with the highest logPow, i.e., a logPow of 6.5 (4,4´-DDT). Therefore the logPow of 2,6-Di-tert-butyl-4-nonylphenol is reported to be > 6.5.

The information is considered relevant and reliable for the risk assessment.

Description of key information

log Pow: > 6.5

Key value for chemical safety assessment

Log Kow (Log Pow):
6.5
at the temperature of:
20 °C

Additional information

In the Klimisch 1 GLP-study Bär (2016) determined the logPow of 2,6-Di-tert-butyl-4-nonylphenol according to OECD 117 (HPLC-method). The retention time of the 2,6-Di-tert-butyl-4-nonylphenol was > 40 min and hence longer than the retention time of the reference material with the highest logPow, i.e., a logPow of 6.5 (4,4´-DDT). Therefore the logPow of 2,6-Di-tert-butyl-4-nonylphenol is reported to be > 6.5.

The information is considered relevant and reliable for the risk assessment.