Registration Dossier
Registration Dossier
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EC number: 224-320-7 | CAS number: 4306-88-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not provided
- Details on results:
- The retention time of the 2,6-Di-tert-butyl-4-nonylphenol was > 40 min and hence longer than the retention time of the reference material with the highest logPow, i.e., a logPow of 6.5 (4,4´-DDT). Therefore the logPow of 2,6-Di-tert-butyl-4-nonylphenol is reported to be > 6.5.
- Conclusions:
- logPow: > 6.5
- Executive summary:
In the Klimisch 1 GLP-study Bär (2016) determined the logPow of 2,6-Di-tert-butyl-4-nonylphenol according to OECD 117 (HPLC-method). The retention time of the 2,6-Di-tert-butyl-4-nonylphenol was > 40 min and hence longer than the retention time of the reference material with the highest logPow, i.e., a logPow of 6.5 (4,4´-DDT). Therefore the logPow of 2,6-Di-tert-butyl-4-nonylphenol is reported to be > 6.5.
The information is considered relevant and reliable for the risk assessment.
Reference
Description of key information
log Pow: > 6.5
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.5
- at the temperature of:
- 20 °C
Additional information
In the Klimisch 1 GLP-study Bär (2016) determined the logPow of 2,6-Di-tert-butyl-4-nonylphenol according to OECD 117 (HPLC-method). The retention time of the 2,6-Di-tert-butyl-4-nonylphenol was > 40 min and hence longer than the retention time of the reference material with the highest logPow, i.e., a logPow of 6.5 (4,4´-DDT). Therefore the logPow of 2,6-Di-tert-butyl-4-nonylphenol is reported to be > 6.5.
The information is considered relevant and reliable for the risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
