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EC number: 224-320-7
CAS number: 4306-88-1
Modification: 1000 / (0,380 *0,1 *(10 / 6,7)
Correction: 1000 / 0,1 (10% absorption)
LD50 > 2000 mg/kg bw.
the oral OECD 422 study in rats, test item related effects on body
weight development, food consumption in male and female high-dose group,
on haematology, coagulation and clinical biochemistry in male and female
300 and 1000 mg/kg dose groups and organ weights effect in all groups
(100, 300, 1000 mg/kg) of males and females were observed.
Histopathologically, in liver, hepatocellular vacuolation was observed
in both surviving and decedent animals. Hepatocyte vacuolation (fatty
changes) was observed in all dose groups and in both males and females.
The observed hepatic change indicates hepatocyte functional alteration /
disturbances related to the administration of
2,6-Di-tert-butyl-4-nonylphenol and the observed hepatic changes were
considered to be adverse. In conclusion, the oral LOAEL = 100 mg/kg bw.
on toxicokinetics evaluation, 100% absorption was considered after oral
exposure, and 10% absorption was considered after inhalation and dermal
Correction: 1000 /0,1 * (1,150)
Correction: 1000 / 0,1 (10% absorption) =
1000 mg/kg bw
(compensation for route)
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