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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Groups of 5 male and 5 female rats were exposed to atmospheres containing either 3.16 or 3.60 mg/l tetrachlorophthalic anhydride for 4 hrs. Animals were held for 14 days for observation, and clinical signs were recorded. After the termination of the study the animals were sacrifieced and a necropsy performed.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Greater than 43 % of the dust particles were < 5 microns in diameter, and > 65% were less than 10 microns.

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
clean air
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
3.16 or 3.60 mg/l. test material
No. of animals per sex per dose:
5 males and 5 females/dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
> 3.6 mg/L air
Based on:
test mat.
Exp. duration:
4 h

Any other information on results incl. tables

No deaths occurred at either test level. 3.6 mg/L was determined to be the maximum attainable concentration using this equipment. No untoward reactions were observed during the exposure or observation periods nor were there any alterations attributable to test material seen at necropsy.

Applicant's summary and conclusion

Executive summary:

Groups of 5 male and 5 female rats were exposed to atmospheres containing either 3.16 or 3.60 mg/l. test material for 4 hrs. Air concentrations were generated using a ferris wheel generator to create a dust and passing clean air through the generator at 30 L/min. to an 80 L. glass and steel chamber containing the animals. Particle size means were calculated. Rats were held for 14 days for observation, then sacrificed and necropsied. Physical signs were recorded.

No deaths occurred at either test level. 3.6 mg/L was determined to be the maximum attainable concentration using this equipment. No untoward reactions were observed during the exposure or observation periods nor were there any alterations attributable to test material seen at necropsy. LC0 > 3.6 mg/l (rat, male + female).