Registration Dossier

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: special investigation

Data source

Reference
Reference Type:
publication
Title:
Effect of tetrachlorophthalic anhydride on hepatic microsomal metabolism in rats and mice
Author:
Ridley WP, Warren J, Nair RS
Year:
1988
Bibliographic source:
J Toxicol Environ Health 24, 217-227

Materials and methods

Principles of method if other than guideline:
The capacity for induction of microsomal metabolic enzymes by tetrachlorophthalic anhydride (TCPA) was evaluated in male Sprague-Dawley rats and male CD-1 mice.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

For rats following the treatment with TCPA a dose-dependent reduction in the zoxazolamine paralysis time occured over the dose range 100 -500 mg/kg was found. No effect on the hexobarbital sleep time was observed at any test level. TCPA was found to produce statistically significant increase in hepatic aminopyrine N-demethylase, aniline hyroxylase, and cytochrome P-450 in the rat at 500 mg/kg bw. In addition statistically significant increases were in aniline hydroxylase and cytochrome P-450 at 25 mg(kg bw.

In mice there was no effect in the zoxazolamine paralysis time or the hexobarbital sleep time. Hepatic microsomal enzyme levels were not measured in the mouse.

Applicant's summary and conclusion

Executive summary:

The capacity for induction of microsomal metabolic enzymes by tetrachlorophthalic anhydride (TCPA) was evaluated in male Sprague-Dawley rats and male CD-1 mice.

The results sugested that following oral dosage TCPA is a weak inducer of microsomal enzymes in the rat. A similar effect was not observed in the mouse for the parameters tested.