Registration Dossier
Registration Dossier
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EC number: 204-171-4 | CAS number: 117-08-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Tetrachlorophthalic anhydride was administered as a single dose gavage to groups of fasted rats to define a Minimum Lethal Dose. The animals were observed for mortality, weight and clinical signs.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Tetrachlorophthalic anhydride
- EC Number:
- 204-171-4
- EC Name:
- Tetrachlorophthalic anhydride
- Cas Number:
- 117-08-8
- Molecular formula:
- C8Cl4O3
- IUPAC Name:
- tetrachloro-1,3-dihydro-2-benzofuran-1,3-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- Doses in mg/kg bw; F = female rats, M = male rats
500 (1 F), 1000 (1 M), 1580 (1F), 2510 (1M), 3980 (1F), 5010 (1M, 1F), 10000 (1M:1F) and 15800 (2M:1F) - No. of animals per sex per dose:
- Doses in mg/kg bw; F = female rats, M = male rats
500 (1 F), 1000 (1 M), 1580 (1F), 2510 (1M), 3980 (1F), 5010 (1M, 1F), 10000 (1M:1F) and 15800 (2M:1F) - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 15 800 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No deaths occurred; some weakness and severe diarrhea were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information
- Executive summary:
Tetrachlorphthalic anhydride was administered as a 33% corn oil suspension via single dose gavage to groups of fasted rats at dosages of 500 (1 F), 1000 (1 M), 1580 (1F), 2510 (1M), 3980 (1F), 5010 (1M, 1F), 10000 (1M:1F) and 15800 (2M:1F) to define a Minimum Lethal Dose. Animals were observed for daily and weighed on day 0 and day 5.
No deaths occurred; some weakness and severe diarrhea were observed. LC0 > 15800 mg/kg bw (rat, male and female)
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