Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable and sufficient documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1965

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Tetrachlorophthalic anhydride was administered as a single dose gavage to groups of fasted rats to define a Minimum Lethal Dose. The animals were observed for mortality, weight and clinical signs.
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
Doses in mg/kg bw; F = female rats, M = male rats
500 (1 F), 1000 (1 M), 1580 (1F), 2510 (1M), 3980 (1F), 5010 (1M, 1F), 10000 (1M:1F) and 15800 (2M:1F)
No. of animals per sex per dose:
Doses in mg/kg bw; F = female rats, M = male rats
500 (1 F), 1000 (1 M), 1580 (1F), 2510 (1M), 3980 (1F), 5010 (1M, 1F), 10000 (1M:1F) and 15800 (2M:1F)
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD0
Effect level:
> 15 800 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

No deaths occurred; some weakness and severe diarrhea were observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Remarks:
Migrated information
Executive summary:

Tetrachlorphthalic anhydride was administered as a 33% corn oil suspension via single dose gavage to groups of fasted rats at dosages of 500 (1 F), 1000 (1 M), 1580 (1F), 2510 (1M), 3980 (1F), 5010 (1M, 1F), 10000 (1M:1F) and 15800 (2M:1F) to define a Minimum Lethal Dose. Animals were observed for daily and weighed on day 0 and day 5.

No deaths occurred; some weakness and severe diarrhea were observed. LC0 > 15800 mg/kg bw (rat, male and female)