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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: case reports

Data source

Reference
Reference Type:
publication
Title:
Occupational asthma due to tetrachlorophthalic anhydride
Author:
Schlueter DP, Banaszak EF, Fink JN, Barboriak J
Year:
1978
Bibliographic source:
J Occup Med 20, 183-188

Materials and methods

Type of sensitisation studied:
respiratory
Study type:
case report
Principles of method if other than guideline:
The patient underwent a complete history and physical examination and routine laboratory studies including chest-x-ray, -ectg, hemogram, chemistry profile, sputum cultures and pulmonary function studies. Inhalation challenge with TCPA was performed to detect hypersensitivity reaction and immunologic studies were performed to demonstrate precipitating or specific IgE antibodies in the workers.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
occupational
Controls:
no data
Route of administration:
inhalation

Results and discussion

Results of examinations:
Inhalation challenge with TCPA reproduced the symptoms and demonstrated both an immeditate and late (4-6 hours) physiologic response.

Any other information on results incl. tables

Although the clinical picture strongly suggested a hypersensitivity reaction, immunologic studies failed to demonstrate precipitating or specific IgE antibody. Avoidance of exposure resulted in resolution of symptoms; however, three of the five individuals had residual functional impairment.

Applicant's summary and conclusion

Executive summary:

Five workers are reported who were involved in the production of exoxy resins and developed recurrent respiratory symptoms and physiologic abnormalities following exposure to tetrachlorophthalic anhydride (TCPA). Inhalation challenge with TCPA reproduced the symptoms and demonstrated both an immeditate and late (4-6 hours) physiologic response.

Although the clinical picture strongly suggested a hypersensitivity reaction, immunologic studies failed to demonstrate precipitating or specific IgE antibody. Avoidance of exposure resulted in resolution of symptoms; however, three of the five individuals had residual functional impairment.