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EC number: 222-720-6
CAS number: 3586-55-8
Study performed according to the OECD
guideline 476. V79 cells were exposed without metabolic activation (MA)
to: 2, 5, 10, 15, 20, 25 µg/ml (3 h exposure); 2, 5, 10, 15, 20, 25
µg/ml (6 h exposure); 1, 2, 5, 7.5, 10, 12.5, 15 µg/ml (repetition 6 h
exposure). With MA the following concentrations were used: 1, 2, 5, 10,
20, 40 µg/ml (3 h exposure); 0.25, 0.5, 1, 2, 5, 10, 20, 40 µg/ml (6 h
exposure) The test substance induced an increased number of mutant cells
with and without metabolic activation. The test substance was considered
to be mutagenic under the condition of this study. Although study
results might be discussed critically due to the fact that mutagenic
effects occurred at concentrations near cytotoxic concentrations.
Results are presumably also due to the hydrolysis product formaldehyde.
Weak mutagenic activity with and without metabolic activation at
concentrations near the cytotoxic range.
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