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EC number: 222-720-6
CAS number: 3586-55-8
The LD50(rat, oral) was determined to
be between 200 and 2000 mg/kg for males and females.
The LD50(rat, dermal) was determined
to be > 2000 mg/kg for males and females.
The test substance was administered once by
gavage to three groups of three rats each following approximately 16 to
20 hours of fasting. Dose levels were 2000 mg/kg bw and 200 mg/kg/bw to
females and 200 mg/kg bw to males, all in 10 mL/kg bw. Clinical
observations were made 1, 2, 3, and 5 hours after dosing and daily
thereafter until termination on Day 15. Bodyweights were recorded on
days 1, 8, and 15. Gross necropsies were performed on all animals.
All animals died at 2000 mg/kg bw, no
mortality was observed at 200 mg/kg bw.
A GLP-compliant acute dermal toxicity
(limit) study was conducted according to OECD Guideline 402 and
Directive 92/69/EC, B.3 without deviation. Five male and five female
HanBrl: Wist (SPF) strain rats were dosed at 2.0 mL/kg bw with undiluted
test material that contained 95% active substance. Clinical signs and
bodyweight development were unafffected during the study. The acute
dermal median lethal dose (LD50) of the test material in rats was found
to be greater than 2000 mg/kg bodyweight.
Labelling, and Packaging Regulation (EC) No 1272/2008
available experimental test data are reliable and suitable for
classification purposes under Regulation (EC) No 1272/2008. Based on
these data, the
test item is classified for acute oral toxicity (Cat. 4, H302) and not
classified for acute dermal and inhalation toxicity according
to Regulation (EC) No 1272/2008 (CLP), as amended for the tenth time in
Regulation (EU) No 2017/776.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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