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EC number: 222-720-6
CAS number: 3586-55-8
Ten female Himalayan spotted guinea pigs
each received intradermal applications of 5% MERGAL V615 in both
purified water and in a 1:1 (v/v) mixture of FCA: physiological saline,
followed a week later by an epidermal application of 50% MERGAL V615 in
purified water (occlusive) during the induction period. Two weeks after
the epidermal induction, the animals received a topical application of
the test article (25% in purified water), which was the previously
determined maximum non-irritating concentration of the test article.
Twenty-one hours after removal of the dressing, treated sites were
depilated as described previously. Five guinea pigs served as controls
that received the intradermal and epidermal inductions without the test
agent. Two weeks after induction, the control animals received challenge
applications of purified water and 25% MERGAL V615 in purified water.
All animals were observed for erythema and oedema at 24 and 48 hours
after removal of the occlusive dressings.
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