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EC number: 222-720-6
CAS number: 3586-55-8
The test substance hydrolyses rapidly
and completely in concentrations which are expected to occur in waste
waters and surface waters. Products of hydrolysis are formaldehyde and
ethylene glycol. Although at high concentrations formaldehyde may
partially still be bound onto ethylene glycol (equilibrium), complete
hydrolysis is expected in the media of the tests on aquatic toxicity.
Data on ethylene glycol are reported
as robust study summaries, while data on formaldehyde are provided as
Data on formaldehyde
Acute toxicity to aquatic organisms
The toxicity to aquatic organisms was
tested in several studies covering different trophic levels.
The acute toxicity of formaldehyde to
fish ranges from LC50(96 h) = 6.7 - 1020 mg/L (OECD 2002). A lower LC50
value of 1.84 mg/L was obtained in a study using the striped bass
(Morone saxatilis) as a test organism. However, due to additional
hypoosmotic stress this value is unreliable and not suitable for risk
assessment. The lowest reliable effect value of 6.7 mg/L was obtained
with the same species. This study was performed in freshwater with fish
acclimated to these conditions, although Morone saxatilis is a marine
species typically living in coastal waters and bays, but also enters the
Acute toxicity towards invertebrates
was tested with the cladocerans Daphnia magna and Daphnia pulex. One 24
h-EC50 is available but should only be used as additional information
since 48 h-values are available from studies according to OECD guideline
202. Further studies using a number of invertebrate species from a wide
array of taxa are reported. LC50s range from 0.42 mg/L to 336.8 mg/L,
but in the light of new results the validity of the lowest value
(Cypridopsis sp. ostracods) has recently been questioned (OECD 2002).
Thus, the lowest reliable 48h-EC50 for invertebrates is 5.8 mg/L (D.
Algal toxicity was found in the same
order of magnitude with EC50s (72 h) of 3.48 mg/L and 4.89 mg/L for
biomass production and growth rate, respectively. Further algal studies
are reported in OECD (2002). With respect to test durations and
endpoints these are rated as not suitable for risk assessment.
Algal and Daphnia tests were performed
according to the OECD guidelines 201 (algae) and 202 (daphnids), while
the fish studies were adhering to national guidelines or were
non-guideline studies. Performance was in all cases in accordance with
general scientific principles and described in sufficient detail. All
studies were conducted without analytical monitoring. However, due to
the very low Henry's law constant and the low adsorption potential of
formaldehyde in water, losses of test substance due to volatilisation
during the test period can be neglected. Therefore, results based on the
nominal concentrations can be regarded as valid.
Studies on the toxicity of
formaldehyde towards aquatic organisms demonstrated that this substance
was acutely toxic to the test organisms.
Chronic toxicity to aquatic organisms
Chronic toxicity towards fish was
investigated in a study comparable to OECD guideline 212. According to
the Technical Notes for Guidance on data requirement (EC 2000, chapter
3) and EU Technical Guidance Document on Risk Assessment (EC 2003, part
II) OECD 212-studies are regarded as long-term tests because the most
sensitive stages in fish development are included. The lowest EC50
obtained in this study is 6.9 mg/L. No NOEC was reported and test
duration was shorter than recommended by OECD guideline 212.
A recently performed study with
Daphnia according to OECD guidelines revealed a 21d NOEC of 6.9 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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