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EC number: 203-907-1
CAS number: 111-78-4
no further remarks
In this two week inhalation study, male rats were exposed to 0, 50, 150
and 500 ppm 1,5 -cyclooctadiene. 10 rats per group were used
for standard toxicological evaluations and 10 rats/group were used for
neurotoxicity testing. No mortalities were reported. In rats
exposed to 500 ppm there was an
absence of alerting response toward the end of the daily 6-hours
exposures. These rats appeared to
recover within 1/2 hour after exposure.
No other test substance-related changes in clinical signs or body weight
observed. Clinical chemistry and haematology showed
no toxicologically important changes. The urinalysis demonstrated an
pH decreases in 500 ppm group at the end of the exposure period, but
not after the recovery period. Histological effects
attributable to the test item were found in the nose and kidneys of the
high dose group. There was a degeneration/necrosis of nasal olfactory
epithelium observed immediately after the exposure period and a
degeneration/regeneration in this area observed after the 2 -week
recovery. In addition , there were increased kidney weights in the 500
ppm group immediatley after exposure, along with increased hyaline
droplets in the kidneys, reversible after the recovery peroid.
Based on the decreased altering response observed in rats during
exposure at 500 ppm, and on the effects observed in the nose, kidney and
urine in rats at this concentration, the no-observed-effect-level (NOEL)
in this study was considered to be 150 ppm.
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