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EC number: 203-907-1
CAS number: 111-78-4
1,5 -Cyclooctadiene is of low to moderate acute toxicity with an oral
LD50 (rat) of 1900 mg/kg bw (Hüls AG, 1983), a dermal LD50 (rabbit) of >
10000 mg/kg bw and an approximate lethal concentration (ALC, rat, 4 h,
vapour) of 12 -19 mg/L after inhalation exposure. The test item may be
fatal if swallowed and enters airways.
In a study according to OECD TG 401 (1981) the test item was applied
once to 4 dose groups of rats (5 male and 5 female Wistar rats per dose
group) in doses of 1250, 1580, 1990, 2510 mg/kg bw undiluted. The
observation period was 14 days.
Some mid-dose animals died between 33 and 120 hours, 9 of 10 high dose
animals died during 96 hours after oral application of the test item.
All dosed animals showed toxic symptoms about 45
minutes after dosing and mostly fading within 6 days after treatment
(one surviving animal from the highest dose group had a ruffled fur even after 14 days).
Reported symptoms are piloerection,
difficult breathing, impairment of balance, staggering gait, tremor, diuresis, abdominal position,
squatting position and sedation.
Post mortem sections showed irritated epithelia of the gastro-intestinal tract and colored spots in the liver. Surviving animals did not
show pathological changes in any tissue after the end of the 14 days observation period.
The LD50 value (oral) was determined to be 1900 (1667-2166) mg/kg bw in
rats for the test item.
no further results
Three groups of 6 male rats each were exposed nose-only for a single, 4
hour period to vapors of the test item in air at chamber vapor
concentrations of 1400, 2700 or 4300 ppm. Mortality was 0/6, 1/6 and 4/6
at 1400, 2700 and 4300 ppm respectively. By 3 hours into the exposure
all rats failed to respond to external sound stimuli. At the end of
exposure, the 2 rats at 4300 ppm and 4 rats at 2700 ppm were immobile.
Threee rats at 1400 ppm exhibited ataxia. Other clinical signs of
toxicity observed after exposure: ocular discharge,
lethargy, irregular respiration. Ocular discharge,
ruffled fur or stained perineum were observed up
to 4 days following exposure.
On an acute inhaltion basis, test item is considered slightly toxic.
no further remarks
In a determination of the acute dermal toxicity on male and female rats
it was found that the LD50 of the test item is greater than 10000 mg/kg.
The treated animals showed signs of toxicity for up to 48 hours. There
was no influence on the increase in body weight. Dissection at the end
of the experiment revealed no evidence of macroscopically detectable
Based on the results of the acute oral and inhalation studies and
according to the criteria of CLP Regulation 1272/2008 1,5 -cyclootadiene
has to be classified as harmful if swallowed and harmful if inhaled.
Based on the results of the acute dermal study the test item has a very
low acute toxicity if it comes in contact with skin. Therefore, 1,5
-cyclooctadiene must not be classified regarding this toxcicological
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