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EC number: 203-907-1
CAS number: 111-78-4
In a study according to OECD TG 401 (1981) the test item was applied
once to 4 dose groups of rats (5 male and 5 female Wistar rats per dose
group) in doses of 1250, 1580, 1990, 2510 mg/kg bw undiluted. The
observation period was 14 days.
Some mid-dose animals died between 33 and 120 hours, 9 of 10 high dose
animals died during 96 hours after oral application of the test item.
All dosed animals showed toxic symptoms about 45
minutes after dosing and mostly fading within 6 days after treatment
(one surviving animal from the highest dose group had a ruffled fur even after 14 days).
Reported symptoms are piloerection,
difficult breathing, impairment of balance, staggering gait, tremor, diuresis, abdominal position,
squatting position and sedation.
Post mortem sections showed irritated epithelia of the gastro-intestinal tract and colored spots in the liver. Surviving animals did not
show pathological changes in any tissue after the end of the 14 days observation period.
The LD50 value (oral) was determined to be 1900 (1667-2166) mg/kg bw in
rats for the test item.
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