Registration Dossier
Registration Dossier
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EC number: 203-254-2 | CAS number: 104-94-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from study report
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : BZ5450000
- Author:
- RTECS handbook
- Year:
- 2 015
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 3,44,1948
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- A study was conducted to evaluate the eye irritation potential of 4- methoxyaniline according to OECD guideline 405 in rabbits
- GLP compliance:
- no
Test material
- Reference substance name:
- p-anisidine
- EC Number:
- 203-254-2
- EC Name:
- p-anisidine
- Cas Number:
- 104-94-9
- Molecular formula:
- C7H9NO
- IUPAC Name:
- 4-methoxyaniline
- Details on test material:
- - Name of test material: 4-methoxyaniline
- Molecular formula: CH3OC6H4NH2
- Molecular weight: 123.15 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Not reported
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Not reported
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- Not reported
- Number of animals or in vitro replicates:
- Not reported
- Details on study design:
- Not reported
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 Hrs
- Reversibility:
- other: Without irreversible effects
- Remarks on result:
- other: other details not known
- Irritant / corrosive response data:
- Not reported
- Other effects:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a study by OECD Guideline 405 4-methoxyaniline after 24 hours of exposure was irritating to the rabbit eye without irreversible effects.
- Executive summary:
A study was conducted to evaluate the eye irritation potential of 4- methoxyaniline according to OECD guideline 405 in rabbits
The tests chemical was applied to rabbit eyes and after 24 hours of dosing effects were observed.
The test chemical was found to be irritant to rabbit eyes without irreversible effects.
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