Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data from study report

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
2001
Reference Type:
review article or handbook
Title:
RTECS Number : BZ5450000
Author:
RTECS handbook
Year:
2015
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances); BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 3,44,1948

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
A study was conducted to evaluate the eye irritation potential of 4- methoxyaniline according to OECD guideline 405 in rabbits
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 4-methoxyaniline
- Molecular formula: CH3OC6H4NH2
- Molecular weight: 123.15 g/mol
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
Not reported

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
Not reported
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
Not reported
Number of animals or in vitro replicates:
Not reported
Details on study design:
Not reported

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 Hrs
Reversibility:
other: Without irreversible effects
Remarks on result:
other: other details not known
Irritant / corrosive response data:
Not reported
Other effects:
Not reported

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In a study by OECD Guideline 405 4-methoxyaniline after 24 hours of exposure was irritating to the rabbit eye without irreversible effects.
Executive summary:

A study was conducted to evaluate the eye irritation potential of 4- methoxyaniline according to OECD guideline 405 in rabbits

The tests chemical was applied to rabbit eyes and after 24 hours of dosing effects were observed.

The test chemical was found to be irritant to rabbit eyes without irreversible effects.