Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data from study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
A study was conducted to evaluate the skin irritation potential of 4- methoxyaniline according to OECD guideline 404 in rabbits
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 4-methoxyaniline
- Molecular formula: CH3OC6H4NH2
- Molecular weight: 123.15 g/mol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
Not reported

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
Not reported
Duration of treatment / exposure:
4 hours
Observation period:
Not reported
Number of animals:
Not reported
Details on study design:
Not reported

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24
Reversibility:
no data
Remarks on result:
other: Not irritating
Irritant / corrosive response data:
Not irritating
Other effects:
Not reported

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In a study for skin irritation according to OECD guideline 404 after 4 hours of dosing of 4-methoxyaniline was not irritating to the rabbit skin.
Executive summary:

A study was conducted to evaluate the skin irritation potential of 4- methoxyaniline according to OECD guideline 404 in rabbits

The tests chemical was applied to rabbit skin and after 4 hours of dosing effects were observed.

The test chemical was found to be non-irritant to rabbit skin.