Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data from study report

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
2001
Reference Type:
review article or handbook
Title:
RTECS Number : BZ5450000
Author:
RTECS handbook
Year:
2016
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances); BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 3,44,1948

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as per mentioned below
Principles of method if other than guideline:
Acute Dermal toxicity study was conducted on rats
GLP compliance:
no
Test type:
other: Not reported

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 4-methoxyaniline
- Molecular formula: CH3OC6H4NH2
- Molecular weight: 123.15 g/mol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
no data
Duration of exposure:
Not reported
Doses:
Not reported
No. of animals per sex per dose:
Not reported
Control animals:
not specified
Details on study design:
Not reported
Statistics:
Not reported

Results and discussion

Preliminary study:
Not reported
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 200 mg/kg bw
Based on:
test mat.
Mortality:
Not reported
Clinical signs:
Not reported
Body weight:
Not reported
Gross pathology:
Not reported
Other findings:
Not reported

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal LD50 in rats after dermal exposure to 4 methoxyaniline is 3200mg/kgw
Executive summary:

Acute Dermal toxicity study was conducted on rats.

The rats were dermally dosed with the test chemical and effects were observed. The acute dermal LD50 in rats after oral exposure to 4 methoxyaniline in 3200mg/kgw