Registration Dossier

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data from study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as per mentioned below
Principles of method if other than guideline:
Acute Oral toxicity study was conducted on rats
GLP compliance:
no
Test type:
other: Not reported

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 4-methoxyaniline
- Molecular formula: CH3OC6H4NH2
- Molecular weight: 123.15 g/mol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
Not reported

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
Not reported
Doses:
Not reported
No. of animals per sex per dose:
Not reported
Control animals:
not specified
Details on study design:
Not reported
Statistics:
Not reported

Results and discussion

Preliminary study:
Not reported
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 400 mg/kg bw
Based on:
test mat.
Remarks on result:
other: The observed effects were hematologic changes , anemia and nephrotoxicity
Mortality:
Not reported
Clinical signs:
Not reported
Body weight:
Not reported
Gross pathology:
Not reported
Other findings:
Not reported

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 in rats after oral exposure to 4 methoxyaniline in 1400mg/kgw
Executive summary:

Acute Oral toxicity study was conducted on rats.

The rats were orally dosed with the test chemical and effects were observed

The observed effects were hematologic changes , anemia and nephrotoxicity

The acute oral LD50 in rats after oral exposure to 4 methoxyaniline in 1400mg/kgw