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Administrative data

Link to relevant study record(s)

Description of key information

There is no information available on the absorption, distribution, metabolism and excretion of p-anisidine in humans. The chemical is known to be absorbed into the body by inhalation of its vapor, through the skin and by ingestion. Considering the high water solubility and low partition co-efficient values, the chemical after absorption is likely to be bio-available for further metabolism. Reports also suggest that it leads to blood damage in living organisms. Thus, it is advised to use the chemical p-anisidine with caution.Since no information is available on the absorption, distribution, metabolism and excretion of p-anisidine in humans, bio-accumulation potential cannot be judged based on the available information.

Key value for chemical safety assessment

Additional information

The test substance p-anisidine can be absorbed into the body by inhalation of its vapor, through the skin and by ingestion.This chemical also has a harmonized classification for acute oral, inhalation and dermal toxicity. Considering the high water solubility and low partition co-efficient values, the chemical after absorption shall be bio-available for metabolism. There is no information on the metabolites formed in humans; though in rabbits it is suggested that p-aminophenol & p-methoxy-n-methylaniline are formed. Reports also suggest that it leads to blood damage in living organisms.

However, since no information is available on the absorption, distribution, metabolism and excretion of p-anisidine in humans,bio-accumulation potential cannot be judgedbased on the available information.