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EC number: 200-661-7
CAS number: 67-63-0
In conclusion, a dose of 1000 mg of isopropanol per kg of body weight
produced evidence of parental effects, as indicated by increases in
absolute and/or relative liver and/or kidney weights compared wtih those
of controls. In addition, increased absolute or relative liver weights
were observed in parental animals dosed with 500 mg/kg compared with
controls. These effects were not considered to be an adverse effect.
However, treatment-related centrilobular hepatocyte hypertrophy was
observed in a few high dose P2 male rats. Increased mortality was
observed in high dose F1 offspring compared with controls. In addition,
high dose offspring of both generations were lighter than controls at
several intervals. Therefore, the parental NOAEL (No Observed Adverse
Effect Level) was established at 500 mg/kg of isopropanol, while the
reproductive NOAEL was established at greater than 1000 mg/kg under the
conditions of this study. The offspring toxicity NOAEL was established
at 500 mg/kg based on reduced offspring body weights and increased
mortality observed at 1000 mg/kg. Subsequent review of the publication
established the offspring toxicity NOAEL at 100 mg/kg bw/day based on
increased mortality at 500 and 1000 mg/kg bw/day and reduced body
weights at 1000 mg/kg bw/day in the F1 and F2 generations. Reprotoxicity
was only observed in the presence of maternal toxicity.
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