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EC number: 200-661-7
CAS number: 67-63-0
A supportive GLP, oral, developmental neurotoxicity study with isopropanol (IPA) conducted according to OECD Guideline 426 in Sprague-Dawley rats reported a NOAEL of 700 mg/kg bw for maternal toxicity effects, and a developmental neurotoxicity NOAEL of 1,200 mg/kg bw (the highest dose tested). A supportive 9 to 13-week inhalational toxicity study in rats (comparable to OECD Guideline 413) did not report a NOAEL at the only concentration level tested (5000 ppm).
According to CLP classification criteria, the substance does meet the
criteria for classification and labelling for this endpoint (STOT single
exposure category 3, H336 - May cause drowsiness or dizziness), as set
out in Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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