Registration Dossier
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EC number: 200-661-7 | CAS number: 67-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
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- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
GLP-guideline study according to OECD guideline 451 in rats is available for IPA. The derived NOAEC is 5000 ppm.
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 12 500 mg/m³
Additional information
A shorter duration key study was a subchronic inhalation study in Fischer 344 rats and CD-1 mice with IPA administered at concentrations of 0, 500, 2500, 5000 ppm for 6 hours/day 5 days/week for 98 days (Burleigh-Flayeret al.,1991). This GLP study was conducted according to OECD test guideline 413. During the 14th week, male and female rats (excluding those animals designated for neuroanatomic pathology evaluation) received 2 and 3 consecutive days of exposure, respectively. The 10 female rats of the 500, 1500, and 5000 ppm group designated for neuroanatomic pathology evaluation were exposed for 1 day during the 14th week; the male rats of the 500, 1500, and 5000 ppm group designated for neuroanatomic pathology evaluation were not exposed during the 14th week. Male and female mice received 4 and 5 consecutive days of exposure during the 14th week, respectively. NOAECs were not identified by the authors. Rats showed acute signs of toxicity (including ataxia, narcosis, lack of a startle reflex, and/or hypoactivity), decreases in absolute body weight and body weight gain, and changes in hematology parameters in animals exposed to 1500 and 5000 ppm of isopropanol, increased relative liver weight in male and female rats exposed to 5000 ppm, as well as increased motor activity for female rats in the 5000 ppm group. Mice showed clinical signs of acute toxicity (including ataxia, narcosis, lack of a startle reflex, and/or hypoactivity) in animals exposed to 1500 and 5000 ppm of isopropanol, increased body weight and body weight gain observed in female mice of the 5000 ppm group, various changes in hematologic and serum clinical chemistry parameters observed in female mice of the 5000 ppm group, and increased relative liver weight in female mice of the 5000 ppm group.
Supportive information on the repeated dose inhalation toxicity of IPA also is provided. A 78-week inhalation oncogenicity study (GLP and based on OECD test guideline 453) in CD-1 mice identified a NOEL[equivalent to a no-observed effect concentration (NOEC)] for toxic effects of 500 ppm due to clinical signs of toxicity and increases in body weights and body weight gains noted at the higher doses, and a NOEL for oncogenicity effects of 5000 ppm (the highest dose tested) as an increased frequency in neoplastic lesions was not noted (Burleigh-Flayer and Wagner, 1993). A 9-day inhalation study in Fischer 344 rats and CD-1 mice conducted according to OECD test guideline 412 was conducted according to GLP (Burleigh-Flayer et al., 1990). Animals were administered IPA for 6 hours/day, 5 days/week at 1000, 5000, 10000, and 15000 ppm. Mortality was observed in rats and mice at the highest two doses. Histologic lesions observed in the kidneys of male rats at 1000 and 5000 ppm are considered to be species and sex specific.
Justification for classification or non-classification
The substance does not meet the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) NO. 1272/2008.
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