Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-661-7 | CAS number: 67-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Isopropanol is associated with low acute oral toxicity. The oral LD50 was reported to be 5840 mg/kg body weight in rats administered the test article by gavage (Smyth and Carpenter, 1948). No other study details were provided.
Isopropanol is associated with low acute dermal toxicity following dermal exposure. Smyth and Carpenter (1948) reported a dermal LD50 for isopropanol of 16.4 mL/kg body weight in rabbits.
Isopropanol was reported to be well tolerated in rats at inhalation exposures up to 1500 ppm for 6 hours (Gill, 1991). At higher dose levels (5000 and 10000 ppm) a number of clinical signs were observed, including transient central system sedation and reversible narcosis. No mortalities were observed at exposures up to 10000 ppm.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 840 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 25 000 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 13 900 mg/kg bw
Additional information
Acute Toxicity: Oral
The potential acute oral toxicity of isopropanol was assessed in rats by Smyth and Carpenter (1948). Although this study is lacking in methodological details, the work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, the results reported by this group are deemed reliable. In their investigation, Smyth
and Carpenter (1948) determined the LD50 of isopropanol in rats to be 5840 mg/kg body weight as assessed following oral gavage administration of a range of isopropanol concentrations in acetone (vehicle) to groups of 6 Sherman rats (reported as 10, 1, 0.1, etc. g/kg body weight). Ispropanol was not classified as acutely toxic following oral exposure according to CLP.)
Acute Toxicity: Dermal
As described above, the work of Smyth and Carpenter (1948) lacks methodological details, but is deemed reliable. These authors examined the potential acute dermal toxicity of isopropanol in 6 rabbits after 24 hours of exposure and reported the LD50 as 16.4 mL/kg body weight. Isopropanol was not classified as acutely toxic following oral exposure according to CLP.
Acute Toxicity: Inhalation
The potential acute inhalation toxicity of isopropanol was assessed in Fischer 344 rats in a study similar in methodology to OECD Guidelines for the Testing of Chemicals No. 403 and in compliance with Good Laboratory Practice (Gill, 1991). Groups of 25 male and 25 female rats were exposed (whole-body) to vapor concentrations of 0, 500, 1500, 5000, or 10000 ppm for 6 hours. The animals were placed in steel chambers with glass doors and windows. The animals were observed for signs of toxicity twice daily and body weights were recorded prior to exposure and at 6 and 24 hours post exposure. No animals died during the study. There were no significant effects on body weight with the exception of a decrease in the 10000 ppm group. The authors reported that this decrease reflected the decrease in food consumption observed during times of prostration and narcosis. In the 5000 ppm group, transient central system sedation was reported in males and females and in the 10000 ppm group reversible narcosis was observed. In the 10000 ppm group, prostration, severe ataxia, decreased arousal, slowed or labored respiration, decreased neuromuscular tone, hypothermia, and loss of reflex function was observed 1 and 6 hours after exposure. Concentration-related decreases in mean motor activity were observed for males in the 1500, 5000, and 10000 ppm groups and females in the 5000 and 10000 ppm groups. Motor activity was severely depressed for males and females in the 10000 ppm group. Exposure-related behavioral changes were not observed in the 500 ppm group. The LD50 was > 10,000 ppm
Isopropanol was not classified as acutely toxic following oral exposure according to CLP.
Justification for classification or non-classification
The substance does not meet the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) NO. 1272/2008.
Specific target organ, Neurotoxicity: According to CLP classification criteria, the substance does meet the criteria for classification and labelling for this endpoint (STOT single exposure category 3, H336 - may cause drowsiness and dizziness) as set out in Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live1