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EC number: 200-661-7
CAS number: 67-63-0
LC50 = 3.2% IPA in diet, 1 day, male Drosophila melanogaster (25.1 g/L in diet)LC50 = 3.4% alcohol, 1 day, female Drosophila melanogaster (26.7 g/L in diet)LC50 = 1.5% alcohol, 2 day, male Drosophila melanogaster (11.8 g/L in diet)LC50 = 1.7% alcohol, 2 day, female Drosophila melanogaster (13.4 g/L in diet)(David & Bocquet, 1976)
The toxicity of 2-propanol to 2 strains of small fruit flies, Drosophila
melanogaster and Drosophila simulans, was assessed in a
published non-guideline study that predates GLP requirements for
ecotoxicity studies (David & Bocquet, 1976). This
laboratory study used larvae grown at low larval density on an axenic,
killed yeast medium. After emergence, adults were
separated into groups of 10 females and 10 males and kept on nutrient
medium for three days. After three days, each group of
flies is transferred into an air-tight plastic vial containing 2 mL of a
3% sucrose solution supplemented with the tested concentration of
2-propanol (7 concentrations in a geometric progression of ratio 1.25). Mortality
was determined after 1, and 2 days of treatment. No
further details on results were reported. The results indicate that the
male fruit fly is more susceptible to 2-propanol toxicity than the
female fruit fly.
Fruit flies are exposed to ethanol from rotting fruits and other
alcohols can also be produced by microorganisms which may be found in Drosophila
food (David & Bocquet, 1976). The metabolism of the alcohols
encountered in food probably has an adaptive ecological significance.
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