Propan-2-ol

Long-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to fish, other

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

Guideline:

other: REACH Guidance on QSARs R.6

Principles of method if other than guideline:

The aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Duration:

28 d

Dose descriptor:

NOELR

Effect conc.:

> 1 000 mg/L

Basis for effect:

growth rate

Conclusions:

The 2-propanol estimated long-term NOELR value is >1000 mg/L based on chronic toxicity of Danio rerio. This value was calculated using the Petrotox computer model, which combines a partitioning model with the Target Lipid Model.

Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The 2-propanol estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is >1000 mg/L based on growth of Danio rerio.

Description of key information

A QSAR using the Target Lipid Model (TLM) reported a long-term NOELR value of >1000 mg/L for Danio rerio.

Additional information

The target lipid model (TLM) has been applied to long-term aquatic endpoints using the Petrotox computer model (version 3.06). As such, modelled data are considered fit for purpose.