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EC number: 200-661-7
CAS number: 67-63-0
The substance was not acutely toxic to freshwater fish when tested according to the methods defined by the US Environmental Protection Agency Committee on Methods for Toxicity Tests with Aquatic Organisms, the substance was determined to possess a 96-hour LC50 in freshwater fish ranging between 9640 and 10000 mg/L.
Three studies addressing short-term toxicity to fish are presented in
Short-term toxicity to fish.001 – 1983 – key: Acute toxicity to the
freshwater fish Pimephales promelas (Fathead minnow) was assessed
according to the methods defined by the US Environmental Protection
Agency Committee on Methods for Toxicity Tests with Aquatic Organisms
not according to GLP (pre-dates GLP requirements). The
study was conducted under flow through conditions under the use of
proportional diluters with 4 fish per concentration (individual test
concentrations not reported) for 96 hours. Temperature
was maintained at 25 ± 1°C and the concentrations were measured in each
tank throughout the test. The percentage of dead fish
was recorded at 1, 3, 6, 12, 24, 48, 72 and 96 hours. The
following validity criteria were met: dissolved oxygen concentrations
remained above 60% of the air saturation value at the end of the test;
and the pH of the control and of the test solution did not vary by more
than one unit during the course of the test. Mortality
of the controls was not reported and although concentrations were
measured throughout the test, individual nominal and measured
concentrations were not reported. Two separate tests
resulted in 96 hour LC50s of 10,000 mg/L and 9640 mg/L.
Short-term toxicity to fish.003 – Golden orf - 1978: Acute toxicity to
the freshwater fish Leuciscus idus melanotus (Golden orf) was
assessed according to Deutsche Einheitsverfahren zur Wasser-, Abwasser-
und Schlammuntersuchung. L 15: Fischtest (Bestimmung der Wirkung von
Wasserinhaltsstoffen auf Fische) not according GLP (pre-dates GLP). The
fish were exposed to the substance under static conditions for 48 hours. The
48 – hour LC50 was determined to range between 8970 and 9280 mg/L. This
lower toxicity over a shorter exposure period is in keeping with the
result of the key study.
Short-term toxicity to fish.002 - Goldfish - 1973: Acute toxicity to the
freshwater fish Carassius auratus (Goldfish) was assessed
according to OECD guideline 203 (Fish, acute toxicity test) not
according GLP (pre-dates GLP). The fish were exposed
to the substance under static conditions for 24 hours. The
median tolerance limit (TLm: the concentration at which 50% animals
survive) at 24 hours was reported to be >5000 mg/L. Detailed
information was not provided in the report however, the results are in
line with the key study. Therefore, result from a non reliable study
however supports the results from the 2 reliable studies presented above.
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