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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer reviewed published data

Data source

Reference
Reference Type:
publication
Title:
Salmonella mutagenicity test results for 250 chemicals
Author:
Haworth S. et al.
Year:
1983
Bibliographic source:
Environmental Mutagenesis, Volume 5, Issue S1, 3-49

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
4-Butyrolactone

Method

Species / strain
Species / strain / cell type:
other: S. typhimurium TA-1535, TA-1537, TA-98, TA-100
Metabolic activation:
with and without
Metabolic activation system:
S9

Results and discussion

Test results
Species / strain:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Any other information on results incl. tables

Preincubation assay (20 min, 37 degr. C, with/without S9-mix).

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation All strains/cell types tested
negative without metabolic activation All strains/cell types tested

Negative in Ames test with and without metabolic acivation.