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EC number: 202-509-5
CAS number: 96-48-0
All high-dose males and one high-dose female died. Males receiving 450
mg/kg gained less body weight. There was no body-weight effect in
females at any dose level. Other than inflammation of the nasal mucosa
in all groups of dosed rats, there were no specific organ effects. The
nasal mucosa irritation was considered to be a non-specific effect of
gavage with a volatile agent. NTP reports that similar lesions have been
observed in other NTP gavage studies with a variety of chemicals and
that the lack of any histologically evident degenerative lesions may be
attributed in part to the rapid absorption and metabolism of the
Rats at the higher dose levels (225 mg/kg and above) showed signs of
sedation after dosing during the first 2-3 weeks of study that
diminished in intensity with continued dosing, and rats showed no
visible signs of sedation after three weeks of dosing. While this effect
is clearly attributable to the test substance, it is not considered
relevant to establishing a chronic NOAEL for workers or consumers except
in cases of accidental poisoning.
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