Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-509-5
CAS number: 96-48-0
According to the National Toxicology Program (NTP, 1996),
γ-Butyrolactone (GBL) is rapidly metabolized to gamma-hydroxybutyric
acid and eliminated primarily as respiratory carbon dioxide and urinary
metabolites. GHB is converted eventually to succinic acid, which enters
the Krebs cycle, eventually being eliminated mainly as carbon dioxide.
GBL shares common segments of its metabolism and toxicokinetic pathway
with 1,4 -Butanediol as well as other compounds that can be metabolized
to gamma-hydroxy butyric acid. Approximately 10% of a dose applied to
the skin of rats, is absorbed (NTP, 1992). A mean permeability constant
of 0.0001 cm/hr (1.1 g/m2/hr) has been estimated (Ursin, 1995).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again