Registration Dossier

Ecotoxicological information

Toxicity to birds

Currently viewing:

Administrative data

Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-guideline, non-GLP, study by a government agency that is well documented in peer reviewed journal and is suitable for evaluating the acute toxicity to birds but does not inform on long-term or reproductive toxicity.

Data source

Reference
Reference Type:
publication
Title:
The Acute Oral Toxicity, Repellency, and Hazard Potential of 998 Chemicals to One or More Species of Wild and Domestic Birds
Author:
Schafer, E.W., et. al
Year:
1983
Bibliographic source:
Arch. Environm. Contam. Toxicol. 12, 355-382

Materials and methods

Principles of method if other than guideline:
As reported by DeCino, T.J., et. al., The Journal of Wildlife Management, Vol. 30, No. 2 (Apr., 1966), pp. 249-253. The acute oral toxicity to wild-trapped red-winged black birds (Agetaius phoeniceus) was determined by intubating a solution of propylene glycol, with the exact microliter dosage calculated according to bird weight and toxicant concentration. Dosage levels were administered in quarter-log steps with four to six birds tested at each level. After being dosed, individual birds were held in the laboratory and observed daily for 7 days, or until death. Birds were preconditioned to captivity for 2 to 6 weeks before initial dosing.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Dose method:
gavage
Vehicle:
yes
Details on preparation and analysis of diet:
Propylene glycol used as vehicle

Test organisms

Test organisms (species):
other: Agetaius phoeniceus
Details on test organisms:
Agetaius phoeniceus (red-winged blackbird)

Study design

Post exposure observation period:
7 days
No. of animals per sex per dose and/or stage:
4 to 6
Nominal and measured doses / concentrations:
Quarter-log steps, presumably: 1.8; 3.2; 5.6; 10; 17.8; 31.6; 56.2; and 100 mg/kg bw.

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 100 mg/kg bw
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Repellency factors (if applicable):
No reported for this substance

Applicant's summary and conclusion