Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-509-5
CAS number: 96-48-0
- Occurs slowly under acidic conditions
- Occurs rapidly under basic conditions
According to studies conducted by U.S. Food and Drug Administration
(Ciolino, L.A., 2001), the pH-hydrolysis studies showed that
γ-Butyrolactone (GBL) hydrolysis occurs under acidic, basic, and neutral
conditions with the rate and extent of conversion to GHB varying widely
according to the solution pH. At ambient temperature, and under strongly
alkaline conditions (pH 12.0), the conversion time frame was within
minutes, with 100% conversion to GHB. Under strongly acidic conditions
(pH 2.0), the conversion time frame was days with the formation of an
equilibrium mixture comprising ca. 2:1 GBL:GHB. In pure water, the same
ca. 2:1 GBL:GBH equilibrium mixture was ultimately formed with gradual
conversion occurring over more than six months storage (202 days) at
ambient temperature. At intermediate pH’s (pH 4.0 to 7.0), conversion to
GHB occurred continually over several months, with the extent of
conversion ranging from 72 to 97% after ca. seven months of storage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again