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EC number: 202-509-5
CAS number: 96-48-0
- Occurs slowly under acidic conditions
- Occurs rapidly under basic conditions
According to studies conducted by U.S. Food and Drug Administration
(Ciolino, L.A., 2001), the pH-hydrolysis studies showed that
γ-Butyrolactone (GBL) hydrolysis occurs under acidic, basic, and neutral
conditions with the rate and extent of conversion to GHB varying widely
according to the solution pH. At ambient temperature, and under strongly
alkaline conditions (pH 12.0), the conversion time frame was within
minutes, with 100% conversion to GHB. Under strongly acidic conditions
(pH 2.0), the conversion time frame was days with the formation of an
equilibrium mixture comprising ca. 2:1 GBL:GHB. In pure water, the same
ca. 2:1 GBL:GBH equilibrium mixture was ultimately formed with gradual
conversion occurring over more than six months storage (202 days) at
ambient temperature. At intermediate pH’s (pH 4.0 to 7.0), conversion to
GHB occurred continually over several months, with the extent of
conversion ranging from 72 to 97% after ca. seven months of storage.
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